|Description||L-685,458, a transition state analogue inhibitor, as a selective and potent inhibitor of γ-secretase (IC50 = 17 nM) it shows > 50-fold selectivity over a variety of aspartyl proteases tested. It is also a potent inhibitor of Aβ40 and Aβ42 peptides (in human neuroblastoma cells: IC50= 48 and 67 nM respectively). in vitro: A Notch inhibitor that blocks Notch activation in the two cell lines in terms of reduced cytoplasmic distribution and almost diminished nuclear labelling of Hes1 proteins; A γ-secretase inhibitor.|
|Brife Description||A potent inhibitor of Aβ40 and Aβ42 peptides (in human neuroblastoma cells: IC50= 48 and 67 nM respectively); A potent and selective γ -secretase inhibitor (IC50 = 17 nM)|
|Synonyms||tert-butyl N-[(2S,3R,5R)-6-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate; 1-benzyl-4-(1-(1-carbamoyl-2-phenylethylcarbamoyl-3-methylbutylcarbamoyl)-2-hydroxy-5; -phenylpentyl)carbamic acid tert-butyl ester; GSI-X cpd; L 685,458; L 685458; L-685,458; L-685458; CHEMBL302004; 292632-98-5; CHEBI:74921; InSolution™ gamma-Secretase Inhibitor X; AC1NUIFT; SCHEMBL3197800; AOB5511; BDBM50100434; ZINC26179223; AKOS024457203; CS-5258; NCGC00165962-01; AK517927; HY-19369; (5S)-(t-Butoxycarbonylamino)-6-phenyl-(4R)hydroxy-(2R)benzylhexanoyl)-L-leu-L-phe-amide; [(2R,4R,5S)-2-Benzyl-5-(Boc-amino)-4-hydroxy-6-phenyl-hexanoyl]-Leu-Phe-NH2; L-Phenylalaninamide, N-(5-(((1,1-dimethylethoxy)carbonyl)amino)-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl)-L-leucyl-,; (2R-(2R*,4R*,5S*))-; N-[(2R,4R,5S)-5-[[(1,1-DImethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6- phenyl-2-(phenylmethyl)hexyl]-L-leucyl-L-phenylalaninamide|
|Solubility||Soluble to 15 mM in DMSO|
|Storage||Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -32℃ for long term (months to years).|
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