CP 615003 mesylate
(CAS: 1259477-42-3)

CP 615003 mesylate is a potent and selective GABAA receptor partial agonist potentially useful in treating generalized anxiety disorder.

Etifoxine
(CAS: 21715-46-8)

Etifoxine, also called as HOE 36801 or Stresam, is a positive allosteric modulator of GABAreceptors that produces anxiolytic effects by preferentially modulatin...

Arbaclofen Hydrochloride
(CAS: 63701-55-3)

Arbaclofen, the R-enantiomer of baclofen, is a selective gamma-amino butyric acid type B receptor agonist used for autism spectrum disorder and fragile X syndro...

2-Hydroxysaclofen
(CAS: 117354-64-0)

2-Hydroxysaclofen is a GABAB receptor antagonist.

FG 7142
(CAS: 78538-74-6)

FG 7142 is a benzodiazepine inverse agonist and anxiogenic agent. FG 7142 increases tyrosine hydroxylation and upregulates β-adrenoceptors in mouse cerebral cor...

adipiplon
(CAS: 840486-93-3)

Adipiplon is GABAA receptor partial agonist. It can bind to the α3 subtype. Adipiplon is one of the first drugs selected for clinical development which is able ...

(±)-Nipecotic acid
(CAS: 60252-41-7)

(±)-Nipecotic acid is a nonselective GAT inhibitor that also induces GABA release through a process termed 'heteroexchange. IC50 = 8, 38, 106 and 2370 μM for hG...

SCS
(CAS: 3232-36-8)

SCS is a potent and selective partial inhibitor of β1-containing GABAA receptors (IC50 = 4.5, 5.3 and 7.9 nM at α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors, res...

SB 205384
(CAS: 160296-13-9)

SB 205384 is a GABAA receptor modulator. SB 205384 potentiates α6, α3 and α5-subunit-containing receptors (EC50 = 280, 695 and 730 nM, respectively). It exhibit...

Tracazolate hydrochloride
(CAS: 1135210-68-2)

Tracazolate hydrochloride is a subtype-selective GABAA receptor modulator that potentiates or inhibits recombinant GABAA function depending on subunit combinati...

3-Methyl-GABA
(CAS: 71424-95-8)

3-Methyl-GABA is an activator of GABA aminotransferase.

Ganaxolone
(CAS: 38398-32-2)

Ganaxolone is a positive allosteric modulator of GABAA receptors with anticonvulsive anxiolytic properties. Ganaxolone enhances GABA-evoked chloride currents in...

CP-457920
(CAS: 220860-50-4)

CP-457920, also called as NGD 971, is a selective α5 GABAA receptor inverse agonist (Ki of ~ 1 ng/mL). CP-457920 was progressed into clinical studies for the tr...

CGP 36216 hydrochloride
(CAS: 123691-29-2)

CGP 36216 hydrochloride is a selective GABAB antagonist that is active to presynaptic receptors but inactive to postsynaptic receptors.

(+)-Bicuculline
(CAS: 485-49-4)

(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.

CGP 52432
(CAS: 139667-74-6)

CGP52432 is a potent and selective GABAB receptor antagonist with IC50 value of 85 nM.

FGIN-1-27
(CAS: 142720-24-9)

FGIN-1-27 is a high affinity agonist of mitochondrial benzodiazepine receptors (PBR) binding to benzodiazepine receptors on mitochondrial membranes. FGIN-1-27 i...

Lesogaberan
(CAS: 344413-67-8)

Lesogaberan is a potent and selective GABAB receptor agonist that limit the clinical use of baclofen for the treatment of GERD.

(R)-baclofen
(CAS: 69308-37-8)

(R)-baclofen a selective GABAB agonist.

Primidone
(CAS: 125-33-7)

Primidone, a pyrimidinedione derivative, could be used as an anticonvulsant agent especially against epilepsy unspecified.