|Targets||Neuropeptide Y receptor|
|Description||L-152,804 is a potent and selective orally available non-peptide neuropeptide Y Y5 receptor antagonist with Ki value of 26 nM for hY5. It displays > 300-fold selectivity over hY1, hY2, and hY4 receptors. It is centrally active upon oral administration in vivo. It causes weight loss in diet-induced obese mice by inducing a potent reduction of food intake in rodents.|
|Purity||≥99% by HPLC|
|Synonyms||L-152,804; L 152,804; L152,804; 5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione; 9-(4,4-Dimethyl-2,6-dioxocyclohexyl)-1,2,3,4-tetrahydro-3,3-dimethyl-1-xanthenone; 9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexenyl)-3,3-dimethyl-4,9-dihydro-2H-xanthen-1-one; L-152804; L152804|
[Leu31,Pro34]-Neuropeptide Y (porcine)
[Leu31,Pro34]-Neuropeptide Y (porcine) is a high affinity neuropeptide Y Y1 receptor agonist (Ki = 0.54 nM).
A Y5 receptor-selective agonist (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki...
Neuropeptide Y (porcine)
Neuropeptide Y (porcine) is a widely distributed endogenous neuropeptide involved in regulation of circadian rhythms, sexual functioning, anxiety and stress res...
Neuropeptide Y (human, rat)
Neuropeptide Y (human, rat) is a widely distributed endogenous neuropeptide involved in the control of food intake, sexual behavior and blood pressure. NPY has ...
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a broad spectrum neuropeptide inverse agonist and antagonist. It acts as a full inverse agonist for the ghrelin re...
CYM 9484 has been found to be an effective neuropeptide Y (NPY) Y2 receptor antagonist.
JNJ 5207787 has been found to be a selective NPY Y2 antagonist (IC50 = 0.1 μM).
BVD 10 is a selective NPY Y1 receptor antagonist (Ki = 25.7, 1420, 2403 and 7100 nM at Y1, Y2, Y4 and Y5 receptors, respectively) with no activity at Y4 recepto...