|Description||KW-2478 is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 antagonist KW-2478 appears to inhibit Hsp90, resulting in impaired signal transduction, inhibition of cell proliferation, and the induction of apoptosis in tumor cells. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation or immune responses.|
|Brife Description||KW-2478 is a nonansamycin Hsp90 inhibitor with IC50 of 3.8 nM.|
|Solubility||DMSO: 115 mg/mL|
|Storage||3 years -20oC powder, 6 months-80oC in solvent.|
|Current Developer||Kyowa Hakko Kirin|
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