Kuromanin chloride - CAS 7084-24-4
Catalog number: 7084-24-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Cyanidin-3-O-glucoside is a anthocyanin that is naturally occurring in various fruits, vegetable and plants that exert a protective effect against endothelial dysfunction and vascular failure induced by peroxynitrite.
Dark Red Solid
Cyanidin-3-O-glucoside chloride; 2-(3,4-Dihydroxyphenyl)-3-(β-D-glucopyranosyloxy)-5,7-dihydroxy-1-benzopyrylium Chloride;
Soluble in DMSO
Store at -20 °C
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Canonical SMILES:
1.Anthocyanidin synthase from Gerbera hybrida catalyzes the conversion of (+)-catechin to cyanidin and a novel procyanidin.
Wellmann F;Griesser M;Schwab W;Martens S;Eisenreich W;Matern U;Lukacin R FEBS Lett. 2006 Mar 6;580(6):1642-8. Epub 2006 Feb 17.
Anthocyanidins were proposed to derive from (+)-naringenin via (2R,3R)-dihydroflavonol(s) and (2R,3S,4S)-leucocyanidin(s) which are eventually oxidized by anthocyanidin synthase (ANS). Recently, the role of ANS has been put into question, because the recombinant enzyme from Arabidopsis exhibited primarily flavonol synthase (FLS) activity with negligible ANS activity. This and other studies led to the proposal that ANS as well as FLS may select for dihydroflavonoid substrates carrying a "beta-face" C-3 hydroxyl group and initially form the 3-geminal diol by "alpha-face" hydroxylation. Assays with recombinant ANS from Gerbera hybrida fully supported the proposal and were extended to catechin and epicatechin isomers as potential substrates to delineate the enzyme specificity. Gerbera ANS converted (+)-catechin to two major and one minor product, whereas ent(-)-catechin (2S,3R-trans-catechin), (-)-epicatechin, ent(+)-epicatechin (2S,3S-cis-epicatechin) and (-)-gallocatechin were not accepted. The K(m) value for (+)-catechin was determined at 175 microM, and the products were identified by LC-MS(n) and NMR as the 4,4-dimer of oxidized (+)-catechin (93%), cyanidin (7%) and quercetin (trace).
2.Cultivar based selection and genetic analysis of strawberry fruits with high levels of health promoting compounds.
Padula MC;Lepore L;Milella L;Ovesna J;Malafronte N;Martelli G;de Tommasi N Food Chem. 2013 Oct 15;140(4):639-46. doi: 10.1016/j.foodchem.2012.11.025. Epub 2012 Nov 16.
Twenty different strawberry genotypes from phenolic compound content and genetic diversity have been investigated. Twelve phenolic derivatives in the strawberry fruit extracts, their total phenolic content (TPC) and their radical scavenging activity have been quantified. In order to study the influence of the genetic basis of each cultivar (cv) on the chemical composition of fruits, Principal Component Analysis of the obtained data was also used. Significant differences in the content of individual anthocyanins among the 20cvs have been found. Pelargonidin 3-O-glucoside was the predominant anthocyanin in the strawberry extracts with 61.0% of the total anthocyanins in Salva cv, followed by cyanidin 3-O-glucoside. TPC values ranged from 129,96 (Laica cv) to 269,04 (Naiad cv) mg of gallic acid equivalent per 100g of fresh weight and it was congruent previous studies. Moreover RAPD markers have been applied in order to describe their genetic relationships. A total of 32decamer primers were used in RAPD analysis; 19 of them provided at least one polymorphic band, the remaining primers were monomorphic. A total of 124 bands were detected with the mean number of 11.53 accountable fragments per primer and 59.
3.Antioxidant and in vitro anticancer activities of phenolics isolated from sugar beet molasses.
Chen M;Meng H;Zhao Y;Chen F;Yu S BMC Complement Altern Med. 2015 Sep 7;15:313. doi: 10.1186/s12906-015-0847-5.
BACKGROUND: ;In the present study, the phenolic compounds were prepared using ultrasonic-aid extraction from sugar beet molasses (SBM).;METHODS: ;Gallic acid (GA), cyanidin-3-O-glucoside chloride (CGC) and epicatechin (EP) were produced after column chromatography from the extraction, and further detected using NMR, QTOF-MS and ESI-MS/MS.;RESULTS: ;The three compounds exhibited strong antioxidant activities including DPPH radical scavenging activities, ABTS radical scavenging activities and ORAC values. GA showed the strongest antioxidant activity. Antitumor activities significantly increased in a dose-dependent manner. In particular, the CGC had growth inhibitory activities of 94.86, 87.27 and 67.13% against the human colon (CACO-2), hepatocellular (HepG2) and breast (MCF-7) carcinoma cell lines, respectively, at the highest concentration of 400 μg/mL of the extracts. These results suggest that the three compounds are key chemical compositions valuable for preparing functional foods in the food industry.;CONCLUSIONS: ;The results suggested that SBM is a natural source of antioxidant and antitumor agents for preparing functional foods.
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CAS 7084-24-4 Kuromanin chloride

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