KT 5823 - CAS 126643-37-6
Catalog number:
126643-37-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C29H25N3O5
Molecular Weight:
495.5
COA:
Inquire
Targets:
Others
Description:
KT 5823 is a cell-permeable, selective inhibitor of cGMP-dependent protein kinase (PKG) (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). KT 5823 is often used in intact cells to assess the role of PKG in signaling, , although there are cases where it poorly inhibits PKG in cells.
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Appearance:
White solid
Synonyms:
2,3,9,10,11,12-hexahydro-10R-methoxy-2,9-dimethyl-1-oxo-9S,12R-epoxy-1H-diindolo[1,2,3-fg:3’,2’,1’-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester;
Solubility:
Soluble to 50 mM in DMSO
Storage:
Desiccate at -20°C
MSDS:
Inquire
Boiling Point:
629.2±55.0 °C | Condition: Press: 760 Torr
Density:
1.52±0.1 g/cm3
InChIKey:
QTYMDECKVKSGSM-MCFVQZIUSA-N
InChI:
1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29?/m0/s1
Canonical SMILES:
COC(=O)[C@@]1(OC)C[C@H]2O[C@@]1(C)n1c3ccccc3c3c4CN(C)C(=O)c4c4c5ccccc5n2c4c13
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CAS 126643-37-6 KT 5823

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