KRX-0601 - CAS 112953-11-4
Catalog number: 112953-11-4
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
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Description:
KRX-0601, also known as UCN-01, is a synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis.
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Synonyms:
UCN-01; Staurosporine; 7-hydroxystaurosporine; KW-2401
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Current Developer:
Kyowa Pharmaceutical, Inc. .
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CAS 112953-11-4 KRX-0601

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