KRH1636 - CAS 568526-77-2
Catalog number: 568526-77-2
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C32H37N7O2
Molecular Weight:
551.70
COA:
Inquire
Targets:
CXCR
Description:
KRH1636 is an orally active, selective and extremely potent CXC chemokine receptor 4(CXCR4) antagonist. It exhibits a potent and selective anti-HIV-1 activity. It efficiently blocked replication of various T cell line-tropic (X4) HIV type 1 (HIV-1) in MT-4 cells and peripheral blood mononuclear cells through the inhibition of viral entry and membrane fusion via the CXCR4 coreceptor. It also inhibits binding of the CXC chemokine, stromal cell-derived factor 1alpha, to CXCR4 specifically and subsequent signal transduction. It prevented monoclonal antibodies from binding to CXCR4 without down-modulation of the coreceptor. It seems to be a promising agent for the treatment of HIV-1 infection.
Purity:
98%
Appearance:
Solid powder
Synonyms:
KRH-1636; KRH 1636; KRH1636. N-[(2S)-5-(diaminomethylideneamino)-1-[[(1S)-1-naphthalen-1-ylethyl]amino]-1-oxopentan-2-yl]-4-[[methyl(pyridin-2-yl)amino]methyl]benzamide;KRH-1636;N-((S)-5-guanidino-1-(((S)-1-(naphthalen-1-yl)ethyl)amino)-1-oxopentan-2-yl)-4-(((pyridin-2-ylmethyl)amino
Solubility:
Soluble in DMSO, not in water
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
KRH1636 seems to be a promising agent for the treatment of HIV-1 infection.
Quality Standard:
In-house standard
Quantity:
Milligrams-Grams
Density:
1.24±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
BTUIXNDDMTVXAR-DWACAAAGSA-N
InChI:
InChI=1S/C32H37N7O2/c1-22(26-12-7-10-24-9-3-4-11-27(24)26)37-31(41)28(13-8-20-36-32(33)34)38-30(40)25-17-15-23(16-18-25)21-39(2)29-14-5-6-19-35-29/h3-7,9-12,14-19,22,28H,8,13,20-21H2,1-2H3,(H,37,41)(H,38,40)(H4,33,34,36)/t22-,28-/m0/s1
Canonical SMILES:
CC(C1=CC=CC2=CC=CC=C21)NC(=O)C(CCCN=C(N)N)NC(=O)C3=CC=C(C=C3)CN(C)C4=CC=CC=N4
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