|Description||KPM-2 is an inhibitor of sirtuin-2 (SIRT2), an NAD-dependent protein deacetylase, which is thought to be involved in cancer progression and in neurodegeneration. It shows antiproliferative activity in cancer cells and inhibits neurite growth. KMP-2 is hopefully used for the treatment of cancer progression and neurodegenerative disorders.|
|Brife Description||inhibitor of sirtuin-2 (SIRT2), cancer progression and neurodegenerative disorders|
|Application||the potential treatment of cancer|
|Current Developer||Ono Pharmaceutical|
SRT1720 is a selective SIRT1 activator with EC50 of 0.16 μM, but is >230-fold less potent for SIRT2 and SIRT3.
KPM-2 is an inhibitor of sirtuin-2 (SIRT2), an NAD-dependent protein deacetylase, which is thought to be involved in cancer progression and in neurodegeneration...
Cambinol is a cell-permeable inhibitor of SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol
AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor (IC50= 12.5 μM) with excellent selectivity against SIRT1 and SIRT3 (IC50 >50 μM, and >50 μM for SI...
EX-527 S-enantiomer is the S-enantiomer of EX-527, which is a potent and selective SIRT1 inhibitor and with no inhibition on SIRT3 and SIRT3.
SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.
AK-7 is a selective and brain-permeable SIRT2 inhibitor, which displays no effect on SIRT1 or SIRT3. It could decrease neuronal cholesterol levels and improve m...
EX-527 R-enantiomer is the R-enantiomer of EX-527, which is a potent and selective SIRT1 inhibitor and with no inhibition on SIRT3 and SIRT3. It is a negative c...
SRT3025 HCl is the hydrochloride form of SRT3025, an agonist of Sirt1. In Fanconi anemia mice, SRT3025 expands hematopoietic stem and progenitor cells as well a...
Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells with...
SRT1720 is a drug developed by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1. It has similar activity in the body ...
Tenovin 6 Hydrochloride
Tenovin-6 is the water soluble analog of Tenovin-1 (HY-13423) and acts as a potent SIRT1 (IC50=21 μM) and SIRT2 (IC50=10 μM) inhibitor as well as p53 activator.
EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3.