KOS-1584 - CAS 1032119-44-0
Catalog number: 1032119-44-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
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Description:
KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration, and reduced CNS exposure. In addition, epothilone KOS-1584 is a poor substrate for the P-glycoprotein (P-gp) drug efflux pump.
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Synonyms:
KOS 1584; 9,10-didehydroepothilone D;   R1645
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Current Developer:
Kosan Biosciences Inc
1.Phase I dose escalation study of KOS-1584, a novel epothilone, in patients with advanced solid tumors.
Lam ET1, Goel S, Schaaf LJ, Cropp GF, Hannah AL, Zhou Y, McCracken B, Haley BI, Johnson RG, Mani S, Villalona-Calero MA. Cancer Chemother Pharmacol. 2012 Feb;69(2):523-31. doi: 10.1007/s00280-011-1724-7. Epub 2011 Aug 27.
PURPOSE: First-in-man study of KOS-1584, a second generation epothilone.
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CAS 1032119-44-0 KOS-1584

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