|Description||Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA4, LPA5, LPA6.|
CYM-5541, also called as ML249, is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM) that less effectively activates S...
Siponimod is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity o...
The modulator of sphingosine-1-phosphate receptor
PF429242, is a reversible, competitive and cell permeable SKI-1/S1P inhibitor (IC50= 175 nM) and demonstrates a very potent and virus-specific antiviral effect ...
Fingolimod, a derivative of the fungal metabolite myriocin, is a antagonist of S1P (IC50 of 0.033 nM) which is an extracellular lipid mediator.
AM095 (Free Acid)
AM095, an effective LPA1 receptor antagonist, has been found to decrease dermal fibrosis caused by attenuates bleomycin. IC50: 0.98 uM and 0.73 uM for human and...
LPA2 antagonist 1
LPA2 antagonist 1 could block the Erk activation regulated by LPA(2) and proliferation of HCT-116 cells as a selective inhibitor of LPA2 protein. IC50: 17 nM (i...
Fingolimod (FTY720) is a S1P antagonist with IC50 of 0.033 nM.
ONO-7300243 is a novel, potent LPA1 (Lysophosphatidic Acid Receptor) antagonist (IC50= 160 nM). In vitro ONO-7300243 showed good membrane permeability and good ...
S1P1 Agonist III
S1P1 Agonist III, a S1P1 agonist, has been found to induce the lymphocyte counts' reduction in circulating blood and have potentials in study of autoimmune dise...
AM966, a LPA1 receptor antagonist, has been found to restrain lung fibrosis in mouse model. IC50: 17 nM.
Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA...