KF-58333 - CAS 308244-21-5
Catalog number:
308244-21-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H27ClN2O7
Molecular Weight:
490.93
COA:
Inquire
Targets:
Hsp90
Description:
KF58333 is a novel derivative of radicicol, binds to the Hsp90 chaperone machinery, depletes p210Bcr-Abl and Raf-1 proteins followed by induction of erythroid differentiation and G1 phase accumulation, and induces apoptosis in human CML cells.
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Brife Description:
KF58333 is a novel Hsp90 inhibitor.
Purity:
>98%
Appearance:
Solid powder
Synonyms:
6H-​Oxireno[e]​[2]​benzoxacyclotetradec​in-​6,​12(7H)​-​dione, 8-​chloro-​1a,​14,​15,​15a-​tetrahydro-​9,​11-​dihydroxy-​14-​methyl-​, 6-​[O-​[2-​(2-​oxo-​1-​pyrrolidinyl)​ethyl]​oxime]​, (1aR,​2Z,​4E,​6E,​14R,​15aR)​- (9CI)
Storage:
3 years -20oC powder, 6 months-80oC in solvent.
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
InChIKey:
XVHHDHWPBRTNET-SOTVZLCNSA-N
InChI:
InChI=1S/C24H27ClN2O7/c1-14-11-20-19(34-20)6-3-2-5-15(26-32-10-9-27-8-4-7-21(27)30)12-16-22(24(31)33-14)17(28)13-18(29)23(16)25/h2-3,5-6,13-14,19-20,28-29H,4,7-12H2,1H3/b5-2-,6-3-,26-15+/t14-,19-,20-/m1/s1
Canonical SMILES:
CC1CC2C(O2)C=CC=CC(=NOCCN3CCCC3=O)CC4=C(C(=CC(=C4Cl)O)O)C(=O)O1
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