|Description||Kevetrin hydrochloride is a water-soluble small molecule with potential antineoplastic activity.|
|Synonyms||UNII-NL6L2371DP; thioureidobutyronitrile; 3-cyanopropyl carbamimidothioate;hydrochloride; Carbamimidothioic acid, 3-cyanopropyl ester, monohydrochloride|
|Solubility||Soluble in DMSO|
|Storage||Store at -20 °C|
|Application||Inhibiting cancer cell growth and causing tumor cell apoptosis.|
|Quality Standard||Enterprise Standard|
|Shelf Life||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly|
MX69 inhibits expression of both MDM2 and XIAP, used for cancer treatment. MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.
NSC 66811 is a MDM2 antagonist. It can disrupt MDM2-p53 interaction.
Pifithrin-β hydrobromide is a reversible inhibitor of p53-dependent transcription and apoptosis, inhibits the growth of the cancer cell lines IGROV-1 (IC50 = 23...
NVP-CGM097 sulfate, a dihydroisoquinolinone derivative, is a potent and selective MDM2 inhibitor (IC50= 1.7±0.1 nM for hMDM2) in the treatment of p53wt tumors.
Nutlin-3 is MDM2 antagonist, inhibits p53-Mdm2 interaction (IC50=0.09 µM).
NVP-HDM201 (HDM201) is a potent and highly specific MDM-2/p53 inhibitor that binds to human Mdm2 protein with a sub-nanomolar Ki value, activates p53 and induce...
Pifithrin-β is a potent p53 inhibitor (IC50=23 uM) in an antiproliferative, showing a conformation similar to those of the prototypical AhR ligand β-naphthoflav...
NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibit...
RITA (NSC 652287)
PRIMA-1, named for p53 reactivation and induction of massive apoptosis, is an inhibitor of the growth of cell lines derived from various human tumor types in a ...
YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction.
Serdemetan, also known as JNJ-26854165, is an orally bioavailable, small-molecule HDM2 antagonist with potential antineoplastic activity. HDM2 antagonist JNJ-2...
SP 141 is a cell-permeable and high affinity MDM2 inhibitor (Ki = 28 nM). SP 141 directly binds MDM2 to inhibit MDM2 expression and induce MDM2 autoubiquitinati...
RO5045337, also known as R7112, RG7112, is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of...
Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.
MI-773, a spirooxindole derivative, is a MDM2 antagonist that has probable effect in the treatment of sorts of cancers. It has already discontinued the Phase I ...
Nutlin-3b, the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM.
MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.