|Description||Kevetrin hydrochloride is a water-soluble small molecule with potential antineoplastic activity.|
|Synonyms||UNII-NL6L2371DP; thioureidobutyronitrile; 3-cyanopropyl carbamimidothioate;hydrochloride; Carbamimidothioic acid, 3-cyanopropyl ester, monohydrochloride|
|Solubility||Soluble in DMSO|
|Storage||Store at -20 °C|
|Application||Inhibiting cancer cell growth and causing tumor cell apoptosis.|
|Quality Standard||Enterprise Standard|
|Shelf Life||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly|
Pifithrin-β is a potent p53 inhibitor (IC50=23 uM) in an antiproliferative, showing a conformation similar to those of the prototypical AhR ligand β-naphthoflav...
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RITA (NSC 652287)
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NVP-CGM097 sulfate, a dihydroisoquinolinone derivative, is a potent and selective MDM2 inhibitor (IC50= 1.7±0.1 nM for hMDM2) in the treatment of p53wt tumors.
Kevetrin hydrochloride is a water-soluble small molecule with potential antineoplastic activity.
Nutlin-3 is MDM2 antagonist, inhibits p53-Mdm2 interaction (IC50=0.09 µM).
Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.