Ketone Ester - CAS 1208313-97-6
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
a ketone ester given orally as R,S-1,3-butanediol acetoacetate diester (BD-AcAc(2)) would delay CNS-OT seizures in rats breathing hyperbaric oxygen (HBO(2)). Adult male rats (n = 60) were implanted with radiotelemetry units to measure electroencephalogram (EEG). One week postsurgery, rats were administered a single oral dose of BD-AcAc(2), 1,3-butanediol (BD), or water 30 min before being placed into a hyperbaric chamber and pressurized to 5 atmospheres absolute (ATA) O2. Beginning at a presymptomatic age, 2 groups of male 3xTgAD mice were fed a diet containing a physiological enantiomeric precursor of ketone bodies (KET) or an isocaloric carbohydrate diet. The results of behavioral tests performed at 4 and 7 months after diet initiation revealed that KET-fed mice exhibited significantly less anxiety in 2 different tests. 3xTgAD mice on the KET diet also exhibited significant, albeit relatively subtle, improvements in performance on learning and memory tests. Immunohistochemical analyses revealed that KET-fed mice exhibited decreased Aβ deposition in the subiculum, CA1 and CA3 regions of the hippocampus, and the amygdala.
Publictions citing BOC Sciences Products
  • >> More
Ketone Ester
1.Carbon nanotube-supported Au-Pd alloy with cooperative effect of metal nanoparticles and organic ketone/quinone groups as a highly efficient catalyst for aerobic oxidation of amines.
Deng W1, Chen J1, Kang J1, Zhang Q1, Wang Y1. Chem Commun (Camb). 2016 Apr 29. [Epub ahead of print]
Functionalised carbon nanotube (CNT)-supported Au-Pd alloy nanoparticles were highly efficient catalysts for the aerobic oxidation of amines. We achieved the highest turnover frequencies (>1000 h-1) for the oxidative homocoupling of benzylamine and the oxidative dehydrogenation of dibenzylamine. We discovered a cooperative effect between Au-Pd nanoparticles and ketone/quinone groups on CNTs.
2.Catalytic transformation of esters of 1,2-azido alcohols into α-amido ketones.
Kim Y1, Pak HK1, Rhee YH1, Park J1. Chem Commun (Camb). 2016 Apr 22. [Epub ahead of print]
The esters of 1,2-azido alcohols were transformed into α-amido ketones without external oxidants through the Ru-catalyzed formation of N-H imines with the liberation of N2 followed by intramolecular migration of the acyl moiety. A wide range of α-amido ketones were obtained, and one-pot transformation into the corresponding oxazoles (or a thiazole) was demonstrated.
3.The synthesis and investigation of impurities found in Clandestine Laboratories: Baeyer-Villiger Route Part I; Synthesis of P2P from benzaldehyde and methyl ethyl ketone.
Doughty D1, Painter B1, Pigou PE1, Johnston MR2. Forensic Sci Int. 2016 Mar 24;263:55-66. doi: 10.1016/j.forsciint.2016.03.034. [Epub ahead of print]
The synthesis of impurities detected in clandestinely manufactured Amphetamine Type Stimulants (ATS) has emerged as more desirable than simple "fingerprint" profiling. We have been investigating the impurities formed when phenyl-2-propanone (P2P) 5, a key ATS precursor, is synthesised in three steps; an aldol condensation of benzaldehyde and methyl ethyl ketone (MEK); a Baeyer-Villiger reaction; and ester hydrolysis. We have identified and selectively synthesised several impurities that may be used as route specific markers for this series of synthetic steps. Specifically these impurities are 3-methyl-4-phenyl-3-buten-2-one 3, 2-methyl-1,5-diphenylpenta-1,4-diene-3-one 9, 2-(methylamino)-3-methyl-4-phenyl-3-butene 16, 2-(Methylamino)-3-methyl-4-phenylbutane 17, and 1-(methylamino)-2-methyl-1,5-diphenylpenta-4-ene-3-one 22.
4.A Hantzsch Amido Dihydropyridine as a Transfer Hydrogenation Reagent for α,β-Unsaturated Ketones.
Van Arman SA1, Zimmet AJ1, Murray IE1. J Org Chem. 2016 Apr 26. [Epub ahead of print]
An improved synthesis of the bis-methylamido Hantzsch dihydropyridine is described. The Hantzsch amide is demonstrated to be an effective transfer hydrogenation reagent using α,β-unsaturated ketones as the test case. Unreacted Hantzsch amide and the bis-methylamidopyridine byproduct are effectively removed by extraction in contrast to the commonly used Hantzsch diethyl ester. Several examples are given with the reaction being more effective for conjugated aromatic substrates than for aliphatics.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

CAS 301-00-8 Methyl linolenate

Methyl linolenate
(CAS: 301-00-8)

Methyl linolenate, a polyunsaturated fattly acid (PUFA), is an autoxidation product that is used to study the mechanisms and prevention of oxidation/peroxidatio...

CAS 22494-42-4 Diflunisal

(CAS: 22494-42-4)

Diflunisal, a salicylic acid derivative, is a non-steroidal anti-inflammatory drug with analgesic and anti-inflammatory activity.

CAS 131-57-7 Oxybenzone

(CAS: 131-57-7)

2-Hydroxy-4-methoxybenzophenone (benzophenone-3) is commonly employed as broad-band UV-filter in sunscreen cosmetic products. It protects skin from the deleteri...

Gepotidacin S enantiomer

Gepotidacin S enantiomer is an S enantionmer of gepotidacin which is a potent Type II DNA topoisomerase inhibitor and appears as a novel antibacterial drug cand...

(CAS: 1219935-54-2)

AM-206 is a bio-active chemical but no detailed data has been published yet.

CAS 125-03-1 Hydrocortamate hydrochloride

Hydrocortamate hydrochloride
(CAS: 125-03-1)

This active molecular is a synthetic glucocorticoid with immunosuppressive and anti-inflammatory properties. Hydrocortamate hydrochloride is applicated for the ...

CAS 2222-07-3 Cucurbitacin I

Cucurbitacin I
(CAS: 2222-07-3)

Cucurbitacin I is a triterpenoid compound which is extracted from some Cucurbitaceae related plants. It was found to be a potential selective inhibitor of JAK2 ...

(CAS: 859230-84-5)

BMS-505130 is a selective serotonin transport inhibitor with Ki of 0.18 nM. Ki value for binding to the norepinephrine is 4.6 mM and for dopamine transporters i...

CAS 82248-59-7 Atomoxetine HCl

Atomoxetine HCl
(CAS: 82248-59-7)

Atomoxetine is a norepinephrine reuptake inhibitor approved for the treatment of attention deficit hyperactivity disorder (ADHD).

CAS 614-39-1 Procainamide Hydrochloride

Procainamide Hydrochloride
(CAS: 614-39-1)

Procainamide, a derivative of procaine with less CNS action., is an agent indicated for production of local or regional anesthesia and in the treatment of ventr...

CAS 6199-67-3 Cucurbitacin B

Cucurbitacin B
(CAS: 6199-67-3)

Cucurbitacin B, an oxygenated tetracyclic triterpenoid compound extracted from Cucurbitaceae plant species, is a long-term anticancer agent by disruption of mic...

CAS 522-12-3 Quercitrin

(CAS: 522-12-3)

Quercitrin is a natural compound extracted from Tartary buckwheat has antiproliferative and apoptotic effects on colon cancer cells.

CAS 236395-14-5 Eslicarbazepine Acetate

Eslicarbazepine Acetate
(CAS: 236395-14-5)

Eslicarbazepine acetate, (BIA 2-093), is a promising antiepileptic drug structurally related to Carbamazepine and Oxcarbazepine.

(CAS: 101708-64-9)

PD-116152 is a novel and highly substituted phenazine. It has antitumor activity. It was isolated from the culture broth of a Streptomyces sp.

CAS 50-99-7 Dextrose

(CAS: 50-99-7)

Dextrose, a simple sugar (monosaccharide), is an important carbohydrate in biology.

CAS 283159-90-0 Valifenalate

(CAS: 283159-90-0)

Valifenalate(IR5885; Valiphenal), which is approved for application on high-value crops such as grapes, tomatoes and other vegetables, is effective against vari...

(CAS: 1375751-08-8)

BMS-955829 shows excellent Metabotropic glutamate receptor 5 (mGluR5) binding affinity, low glutamate fold shift, and high selectivity for the mGluR5 subtype. B...

CAS 2199-58-8 PYR-9588

(CAS: 2199-58-8)

PYR-9588 is an intermediate used in the chemical synthesis of a series of anaplastic lymphoma kinase (ALK) inhibitors.

CAS 1184136-10-4 UNC-926

(CAS: 1184136-10-4)

UNC-926 is a methyl-lysine (Kme) reader domain inhibitor which binds to the MBT domain of L3MVTL protein (IC50= 3.9 μM).

CAS 509-20-6 Aconine

(CAS: 509-20-6)

Aconine is extracted form the roots of Aconitum kusnezoffii Reichb, a derivative of Aconitine.

Chemical Structure

CAS 1208313-97-6 Ketone Ester

Quick Inquiry

Verification code

Featured Items