|Description||Potent blocker of voltage-sensitive K+ channels (IC50 values are 0.1, 1.1 and 25 nM for KV1.3, KV1.1 and KV1.2 channels) respectively). Also inhibits Ca2+-activated K+ channels.|
An inhibitor of MAO.
Duocarmycin B1 is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates.
Tubulysin B is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates.
Dantrolene sodium is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. It achieves this by inhibiting Ca2+ ions relea...
Tschimgine a substance presenting an estrogenic activity..
Tetrahydroberberine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Tetrahydroberber...
Alkaloid , from plants of the Ranunculaceae family. Ganglioblocker; nicotinic receptor antagonist; hypotensive; presents micromolar affinity at brain a Bungarot...
Synthetic, a neuronal nicotinic AChR antagonist.
a CNS stimulant. Alkaloid, , purified from plants of Coffea genus, Rubiaceae.
Conantokin-G is a conopeptide that has been isolated from the venom of the cone Conus geographus. Conantokin-G selectively inhibits NR2B containing N-methyl-D-a...
Mesaconitine has antinociceptive activity through cyclic AMP and stimulation of the central β-adrenergic system.
Synthetic, nicotinic AChR. Rigid bicyclic analog of TMA and TEA.
ω-agatoxin-IVA (ω-AGA IVA) is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calc...
A potent antiarrhytmic and local anesthetic. Alkaloid , from plants of the Ranunculaceae family. Inhibitorand Enhancers of Uridine Diphosphate-Glucuronosyltrans...
A cytostatic substance Isotryptamine.
A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and ...
Irofulven is a semisynthetic sesquiterpene derivative of illudin S, a natural toxin isolated from the fungus Omphalotus illudens. Irofulven alkylates DNA and pr...
Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influen...
Synthetic, a selective irreversible inhibitor of carboxylesterases
Diamine oxidase activator. Na+ channels blocker.