Kaempferol-3-β-O-glucuronide - CAS 22688-78-4
Catalog number: 22688-78-4
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Chemical Family:
Kaempferol-3-beta-O-glucuronide belongs flavonoid glucuronides, which can be found in vegetables and deconjugated by microsomal β-glucuronidase from various human cells.
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Yellow powder
3-(β-D-Glucopyranuronosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 3-(β-D-Glucurono pyranosyloxy)-5,7,4'-trihydroxyflavone; 4',5,7-Trihydroxyflavon-3-yl β-D-glucopyranosiduronic acid; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-3-yl-beta-D-glucopyranosiduronic acid; Kaempferol 3-O-β-D-glucuronide
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1.Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans.
DuPont MS;Day AJ;Bennett RN;Mellon FA;Kroon PA Eur J Clin Nutr. 2004 Jun;58(6):947-54.
OBJECTIVE: ;To determine the absorption, excretion and metabolism of kaempferol in humans.;DESIGN: ;A pharmacokinetic study of kaempferol from endive over 24 h.;SUBJECTS: ;Four healthy males and four healthy females.;RESULTS: ;Kaempferol, from a relatively low dose (9 mg), was absorbed from endive with a mean maximum plasma concentration of 0.1 microM, at a time of 5.8 h, indicating absorption from the distal section of the small intestine and/or the colon. Although a 7.5-fold interindividual variation between the highest and lowest maximum plasma concentration was observed, most individuals showed remarkably consistent pharmacokinetic profiles. This contrasts with profiles for other flavonoids that are absorbed predominantly from the large intestine (eg rutin). An average of 1.9% of the kaempferol dose was excreted in 24 h. Most subjects also showed an early absorption peak, probably corresponding to kaempferol-3-glucoside, present at a level of 14% in the endive.
2.Superoxide scavenging by polyphenols: effect of conjugation and dimerization.
Cano A;Arnao MB;Williamson G;Garcia-Conesa MT Redox Rep. 2002;7(6):379-83.
The superoxide anion scavenging capacity of two flavonols (quercetin and kaempferol) and some of their conjugates (quercetin-3-rhamnoglucoside, quercetin-3-sophoroside, quercetin-3-sulphate, quercetin-3-glucuronide, kaempferol-3-sophoroside, kaempferol-3-glucuronide) and of several hydroxycinnamic acids (caffeic acid, ferulic acid, 5-5 diferulic acid, 8-O-4 diferulic acid and 8-8 diferulic acid) were studied. Superoxide anions were generated non-enzymatically in a phenazine methosulphate-NADH system and assayed by reduction of nitro-blue tetrazolium. Among the flavonols examined, the most effective scavengers of superoxide anions were the sophoroside, glucuronide and rhamnoglucoside conjugates. Conversely, quercetin-3-sulphate and the flavonol aglycones, exhibited some pro-oxidant activity at the range of concentrations tested (0.5-10 microM). These results show that conjugation has a marked effect on the scavenging capacity of flavonols and that the type of conjugate at the 3-position determines the final superoxide scavenging capacity.
3.Effects of preharvest ultraviolet-C irradiation on fruit phytochemical profiles and antioxidant capacity in three strawberry (Fragaria × ananassa Duch.) cultivars.
Xie Z;Charles MT;Fan J;Charlebois D;Khanizadeh S;Rolland D;Roussel D;Deschênes M;Dubé C J Sci Food Agric. 2015 Nov;95(14):2996-3002. doi: 10.1002/jsfa.7064. Epub 2015 Jan 21.
BACKGROUND: ;Ultraviolet-C (UV-C) has proven effective in extending shelf-life, reducing disease incidence and increasing the levels of health-promoting compounds in several crops. While most studies were conducted at the postharvest stage, our study examined the effect of preharvest UV-C application in three strawberry cultivars (Fragaria × ananassa Duch. 'Albion', 'Charlotte' and 'Seascape'). UV-C treatment was applied from the onset of flowering until the fruits reached commercial maturity on plants grown for two consecutive seasons under greenhouse conditions. The phytochemical profiles and antioxidant capacity of the fruits were assessed at harvest.;RESULTS: ;The ellagic acid and kaempferol-3-glucuronide contents were significantly increased only in fruits of the cultivar 'Albion' collected from UV-C-treated plants in season 1. UV-C did not consistently affect the other phenolic compounds that were measured. Based on the results of the ferric-reducing antioxidant power, oxygen radical absorbance capacity and total phenolic content assays, the antioxidant capacity of the three strawberry cultivars was not affected by UV-C.
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CAS 22688-78-4 Kaempferol-3-β-O-glucuronide

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