Kaempferide - CAS 491-54-3
Catalog number:
491-54-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H12O6
Molecular Weight:
300.26
COA:
Inquire
Targets:
Others
Description:
Kaempferide is an O-methylated flavonol. It can be found in Kaempferia galanga (aromatic ginger). The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Kaempferol 4'-O-methyl ether
MSDS:
Inquire
1.You-gui Pill ameliorates renal tubulointerstitial fibrosis via inhibition of TGF-β/Smad signaling pathway.
Wang L1, Cao AL1, Chi YF2, Ju ZC3, Yin PH2, Zhang XM4, Peng W5. J Ethnopharmacol. 2015 Jul 1;169:229-38. doi: 10.1016/j.jep.2015.04.037. Epub 2015 Apr 25.
ETHNOPHARMACOLOGICAL RELEVANCE: You-gui Pill (YGP), a traditional Chinese medicinal prescription, was widely used to warm and recuperate "kidney-yang" clinically for hundreds of years in China. Recent studies found that YGP had a potential benefit for renoprotection.
2.Synthesis of kaempferide Mannich base derivatives and their antiproliferative activity on three human cancer cell lines.
Nguyen VS1, Shi L2, Luan FQ2, Wang QA2. Acta Biochim Pol. 2015;62(3):547-52. doi: 10.18388/abp.2015_992. Epub 2015 Sep 8.
Kaempferide (3,5,7-trihydroxy-4'-methoxyflavone, 1), a naturally occurring flavonoid with potent anticancer activity in a number of human tumour cell lines, was first semisynthesized from naringin. Based on Mannich reaction of kaempferide with various secondary amines and formaldehyde, nine novel kaempferide Mannich base derivatives 2-10 were synthesized. The aminomethylation occurred preferentially in the position at C-6 and C-8 of the A-ring of kaempferide. All the synthetic compounds were tested for antiproliferative activity against three human cancer cell lines (Hela, HCC1954, SK-OV-3) by the standard MTT method. The results showed that compounds 1, 2 and 5-10 were more potent against Hela cells with IC50 values of 12.47-28.24 μM than the positive control cis-platin (IC50 41.25 μM), compounds 5, 6, 8 and 10 were more potent against HCC1954 cells with IC50 values of 8.82-14.97 μM than the positive control cis-platin (IC50 29.68 μM), and compounds 2, 3, 5, 6 and 10 were more potent against SK-OV-3 cells with IC50 values of 7.
3.Characterization of Non-Anthocyanic Flavonoids in Some Hybrid Red Grape Extracts Potentially Interesting for Industrial Uses.
De Rosso M1, Panighel A2, Vedova AD3, Gardiman M4, Flamini R5. Molecules. 2015 Oct 2;20(10):18095-106. doi: 10.3390/molecules201018095.
Previous studies showed that hybrid grapes often have qualitatively and quantitatively higher polyphenolic contents than the common V. vinifera grape varieties. In general, these compounds are studied for grape chemotaxonomy and for nutraceutical purposes due to their relevant antioxidant activity. Non-anthocyanic flavonoid composition of five red hybrid grape varieties produced by crossing of V. vinifera, V. aestivalis, V. cinerea, V. berlandieri, V. labrusca, V. lincecumii, and V. rupestris were studied by liquid chromatography/high-resolution mass spectrometry. Thirty-one compounds were identified, including methylnaringenin, a tetrahydroxy-dimethoxyflavanone-hexoside, two flavonols (quercetin and a pentahydroxyflavone isomer), 20 glycoside flavonols (four quercetin, two myricetin, two kaempferol, three isorhamnetin, one laricitrin, two syringetin, one kaempferide and two dihydroflavonol derivatives; myricetin-glucoside-glucuronide; myricetin-diglucoside; syringetin-dihexoside), three flavan-3-ols (-)-epicatechin, (+)-catechin, (-)-epicatechin gallate) and four proantocyanidins (procyanidin B1, procyanidin B2, procyanidin B3 or B4/B5, procyanidin T2 or T3/T4/C1).
4.Isolates of Alpinia officinarum Hance as COX-2 inhibitors: Evidence from anti-inflammatory, antioxidant and molecular docking studies.
Honmore VS1, Kandhare AD2, Kadam PP2, Khedkar VM3, Sarkar D3, Bodhankar SL4, Zanwar AA5, Rojatkar SR6, Natu AD7. Int Immunopharmacol. 2016 Apr;33:8-17. doi: 10.1016/j.intimp.2016.01.024. Epub 2016 Feb 3.
BACKGROUND: Inflammation triggered by oxidative stress can cause various ailments, such as cancer, rheumatoid arthritis, asthma, diabetes etc. In the last few years, there has been a renewed interest in studying the antioxidant and anti-inflammatory action of plant constituents such as flavonoids and diarylheptanoids.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 129-06-6 Warfarin sodium

Warfarin sodium
(CAS: 129-06-6)

Warfarin is an anticoagulant applicated in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migrati...

CAS 1126-61-0 4-Allylcatechol

4-Allylcatechol
(CAS: 1126-61-0)

4-Allylcatechol is an intermediate to synthetic safrole and was used in a study performed to evaluate the phenolic content, antioxidant and antimicrobial activi...

CAS 3771-19-5 Nafenopin

Nafenopin
(CAS: 3771-19-5)

Nafenopin is a hypolipidemic agent, a peroxisome proliferator, on the activities of rat liver glutathione-requiring enzymes and catalase in comparison to the ac...

Bisegliptin
(CAS: 862501-61-9)

Bisegliptin is an antidiabetic agent, but no detailed information has been published yet.

CAS 77303-18-5 AR-L 100 BS

AR-L 100 BS
(CAS: 77303-18-5)

AR-L 100 BS is a bio-active chemical with cardiovascular effects originated by oehringer Ingelheim Pharma KG. But no development was reported for Ischaemic hear...

CAS 1646-88-4 Aldicarb sulfone

Aldicarb sulfone
(CAS: 1646-88-4)

Aldicarb Sulfone is an analog of Aldicarb detected in agricultural products as pesticide residue.

BMS-955829
(CAS: 1375751-08-8)

BMS-955829 shows excellent Metabotropic glutamate receptor 5 (mGluR5) binding affinity, low glutamate fold shift, and high selectivity for the mGluR5 subtype. B...

CAS 128794-94-5 Mycophenolate Mofetil

Mycophenolate Mofetil
(CAS: 128794-94-5)

Mycophenolate Mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respect...

LY-207702
(CAS: 103828-81-5)

LY-207702 is a difluorinated purine nucleoside. It exhibits antitumor activity in preclinical models. It was developed by Eli Lilly & Co.

CAS 56180-94-0 Acarbose

Acarbose
(CAS: 56180-94-0)

Acarbose is an inhibitor of intestinal alpha-glucosidase, used to treat type 2 diabetes mellitus.

LY 135114
(CAS: 126254-82-8)

LY 135114 is a metabolite of LY 195448. LY195448 is a Alpha adrenergic receptor originate by Eli Lilly. But clinical trials for the treatment of cancer had been...

CAS 135062-02-1 Repaglinide

Repaglinide
(CAS: 135062-02-1)

Repaglinide is a potassium channel blocker, which lowers blood glucose by stimulating the release of insulin from the pancreas, used the treatment of type II di...

CAS 406-76-8 DL-Carnitine

DL-Carnitine
(CAS: 406-76-8)

Carnitine regulates fatty acid transport in mitochondria, elevates serum carnitine fractions.

CAS 50-01-1 Guanidine Hydrochloride

Guanidine Hydrochloride
(CAS: 50-01-1)

Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denatur...

CAS 98-92-0 Nicotinamide

Nicotinamide
(CAS: 98-92-0)

Nicotinamide, a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an activator of sirtuins.

CAS 6106-07-6 L-Thyroxine sodium salt pentahydrate

L-Thyroxine sodium salt pentahydrate
(CAS: 6106-07-6)

L-Thyroxine sodium salt pentahydrate is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells. It reduces total cholesterol l...

LY 255262
(CAS: 124986-45-4)

This bio-active molecular is a antibacterial agent with a pyrazolidinone structure.

CAS 51014-29-0 Isocorynoxeine

Isocorynoxeine
(CAS: 51014-29-0)

Isocorynoxeine is a alkaloid extracted from Uncaria Hook shows the effects of lowering blood pressure.

CAS 68252-28-8 (R)-Oxiracetam

(R)-Oxiracetam
(CAS: 68252-28-8)

(R)-Oxiracetam is the (R)-enantiomer of the nootropic drug oxiracetam, which is a nootropic drug of the racetam family and stimulant. It is safe even when high ...

CAS 168021-79-2 Disufenton Sodium

Disufenton Sodium
(CAS: 168021-79-2)

The sodium salt form of Disufenton, a benzenesulfonate compound, has been found to be a free radical scavenger that was once studied in acute ischaemic stroke t...

Chemical Structure

CAS 491-54-3 Kaempferide

Quick Inquiry

Verification code

Featured Items