K145 hydrochloride - CAS 1449240-68-9
Catalog number:
1449240-68-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H25ClN2O3S
Molecular Weight:
384.92
COA:
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Targets:
SPHK
Description:
K145 (3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione) is a selective inhibitor of sphingosine kinase-2 (SphK2) and an anticancer agent. K145 selectively inhibited SphK2 in a dose-dependent manner with an IC50 of 4.30 +/- 0.06 μM with no inhibition of SphK1 at concentrations up to 10 μM. K145 significantly suppressed the growth of U937 tumors in nude mice and the growth of JC tumor cells in BALB/c mice.
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Purity:
>98%
Synonyms:
SphK2 inhibitor; K 145 hydrochloride; K-145 hydrochloride
MSDS:
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CAS 1449240-68-9 K145 hydrochloride

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