K-7174 dihydrochloride - CAS 191089-60-8
Catalog number: 191089-60-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C33H50Cl2N2O6
Molecular Weight:
641.67
COA:
Inquire
Targets:
Others
Description:
K-7174, one of proteasome inhibitory homopiperazine derivatives, exhibits a therapeutic effect, which is stronger when administered orally than intravenously, without obvious side effects in a murine myeloma model. Moreover, K-7174 kills bortezomib-resistant myeloma cells carrying a β5-subunit mutation in vivo and primary cells from a patient resistant to bortezomib.
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Purity:
>98%
Related CAS:
191089-59-5 (Free base)
Appearance:
White to off-white solid powder
Synonyms:
1,4-bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-en-1-yl)-1,4-diazepane dihydrochloride; K7174; K 7174; K-7174; K-7174-2HCl; K-7174 dihydrochloride
MSDS:
Inquire
InChIKey:
JKAQFPBRMVEHBD-CHBZAFCASA-N
InChI:
1S/C33H48N2O6.2ClH/c1-36-28-22-26(23-29(37-2)32(28)40-5)14-9-7-11-16-34-18-13-19-35(21-20-34)17-12-8-10-15-27-24-30(38-3)33(41-6)31(25-27)39-4;;/h9-10,14-15,22-25H,7-8,11-13,16-21H2,1-6H3;2*1H/b14-9+,15-10+;;
Canonical SMILES:
COC1=C(OC)C(OC)=CC(/C=C/CCCN2CCN(CCC/C=C/C3=CC(OC)=C(OC)C(OC)=C3)CCC2)=C1.[H]Cl.[H]Cl
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CAS 191089-60-8 K-7174 dihydrochloride

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