K-7174 dihydrochloride - CAS 191089-60-8
Catalog number: 191089-60-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C33H50Cl2N2O6
Molecular Weight:
641.67
COA:
Inquire
Targets:
Others
Description:
K-7174, one of proteasome inhibitory homopiperazine derivatives, exhibits a therapeutic effect, which is stronger when administered orally than intravenously, without obvious side effects in a murine myeloma model. Moreover, K-7174 kills bortezomib-resistant myeloma cells carrying a β5-subunit mutation in vivo and primary cells from a patient resistant to bortezomib.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Related CAS:
191089-59-5 (Free base)
Appearance:
White to off-white solid powder
Synonyms:
1,4-bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-en-1-yl)-1,4-diazepane dihydrochloride; K7174; K 7174; K-7174; K-7174-2HCl; K-7174 dihydrochloride
MSDS:
Inquire
InChIKey:
JKAQFPBRMVEHBD-CHBZAFCASA-N
InChI:
1S/C33H48N2O6.2ClH/c1-36-28-22-26(23-29(37-2)32(28)40-5)14-9-7-11-16-34-18-13-19-35(21-20-34)17-12-8-10-15-27-24-30(38-3)33(41-6)31(25-27)39-4;;/h9-10,14-15,22-25H,7-8,11-13,16-21H2,1-6H3;2*1H/b14-9+,15-10+;;
Canonical SMILES:
COC1=C(OC)C(OC)=CC(/C=C/CCCN2CCN(CCC/C=C/C3=CC(OC)=C(OC)C(OC)=C3)CCC2)=C1.[H]Cl.[H]Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 131179-95-8 Efaproxiral

Efaproxiral
(CAS: 131179-95-8)

synthetic small molecule with radiosensitizing activity. Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobi...

LTV-1
(CAS: 347379-29-7)

LTV-1, a highly potent inhibitor, inhibits LYP((IC50 = 508 nM)) in a dose-dependent manner at low- and sub-micromolar concentrations in T cells.

OT-R antagonist 2
(CAS: 364071-16-9)

OT-R antagonist 2 is a nonpeptide OT-R antagonist, inhibitis IP3-Synthesis, rat OT-R (IC50 = 0.33 μM).

MK 1-907
(CAS: 78150-06-8)

MK-1-907 is a centrally acting drug, but no detailed information has been published yet.

CP-60949-4
(CAS: 17518-97-7)

CP-60949-4, a quinazolin derivative, could be probably useful in sorts of biological studies.

CAS 3771-19-5 Nafenopin

Nafenopin
(CAS: 3771-19-5)

Nafenopin is a hypolipidemic agent, a peroxisome proliferator, on the activities of rat liver glutathione-requiring enzymes and catalase in comparison to the ac...

FR-182024
(CAS: 179034-83-4)

FR-182024, an azabicyclo derivative, has been found to have potential activity as an anti-Helicobacter pylori agent and was once stuied against helicobacter inf...

CAS 71320-77-9 Moclobemide

Moclobemide
(CAS: 71320-77-9)

Moclobemide is a reversible monoamine oxidase A (MOA-A) inhibitor.

CAS 611-75-6 Bromhexine Hydrochloride

Bromhexine Hydrochloride
(CAS: 611-75-6)

Bromhexine is a mucolytic (expectorant) agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine ...

CAS 107868-30-4 Exemestane

Exemestane
(CAS: 107868-30-4)

Exemestane is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.

CAS 770691-21-9 Gadobutrol

Gadobutrol
(CAS: 770691-21-9)

Gadobutrol is a nonionic, paramagnetic contrast agent developed for tissue contrast enhancement in magnetic resonance imaging (MRI). It has a macrocyclic framew...

CAS 1187-84-4 S-Methyl-L-cysteine

S-Methyl-L-cysteine
(CAS: 1187-84-4)

S-Methyl-L-cysteine, a theurapeutic for neurodegenerative diseases, is a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductas...

CAS 20362-31-6 Arctiin

Arctiin
(CAS: 20362-31-6)

Arctiin has shown to be a suppressor of cyclin D1 protein expression in multiple types of human tumor cells, such as osteosarcoma, lung, colorectal, cervical, b...

CAS 1223001-53-3 STK16-IN-1

STK16-IN-1
(CAS: 1223001-53-3)

STK16-IN-1, a pyrrolonaphthyridinone compound, only potently inhibited STK16 (relative activity remaining 0.65%) and mTOR (relative activity remaining 0.4%) at ...

CAS 13721-39-6 Sodium orthovanadate

Sodium orthovanadate
(CAS: 13721-39-6)

Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.

CAS 483-34-1 (-)-Isocorypalmine

(-)-Isocorypalmine
(CAS: 483-34-1)

(-)-Isocorypalmine is a alkaloid, as a metabolite of the isoquinoline.

CAS 97759-16-5 S186

S186
(CAS: 97759-16-5)

S186 is a kind of sodium salts of calcium-acetylpropylamine phosphonate(APA). It is a new strontium-specific chelating agent. It has also been approved by Shang...

CAS 36051-31-7 5(acute)-GTP trisodium salt

5(acute)-GTP trisodium salt
(CAS: 36051-31-7)

Guanosine 5'-(tetrahydrogen triphosphate) Trisodium Salt, is the salt form of GTP, which is a substrate for the synthesis of RNA during the transcription proces...

CAS 304-20-1 Hydralazine hydrochloride

Hydralazine hydrochloride
(CAS: 304-20-1)

Hydralazine HCl is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM.

CAS 3863-59-0 Hydrocortisone phosphate

Hydrocortisone phosphate
(CAS: 3863-59-0)

Hydrocortisone is a corticosteroid increases blood sugar through gluconeogenesis to suppress the immune system.

Chemical Structure

CAS 191089-60-8 K-7174 dihydrochloride

Quick Inquiry

Verification code

Featured Items