|Targets||Amyloid-β | γ-secretase|
|Description||K 01-162 binds and destabilizes AβO (β-amyloid( EC50= 0.080 mM; IC50= 80 nM), can reduce the brain amyloid burden that exists in both fibrillar and RIPA-soluble, non-fibrillar forms.|
|Synonyms||7-bromo-N,N-dimethyl-9H-fluoren-2-amine; 9H-Fluoren-2-aMine, 7-broMo-N,N-diMethyl-;|
|Solubility||Soluble in DMSO|
|Storage||Store at -20 °C|
|Application||Stabilizes hydrophobic core I of Aβ42 peptide (residues 17-21) to its α-helical conformation by interacting specifically in this region. in vivo|
|Quality Standard||Enterprise Standard|
|Shelf Life||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly|
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