JZP 361 - CAS 1680193-80-9
Category: Inhibitor
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Molecular Formula:
C22H20ClN5O
Molecular Weight:
405.88
COA:
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Targets:
MAGL
Description:
JZP 361 is a reversible, potent and selective inhibitor of human recombinant MAGL (hMAGL) with IC50 value of 46 nM. It shows affinity for H1 receptors but shows no activity at cannabinoid receptors. It has MAGL-inhibitory and antihistaminergic and may be a novel dual-acting pharmacological tool.
Purity:
≥99% by HPLC
Synonyms:
JZP-361; JZP 361; JZP361; [4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone
MSDS:
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InChIKey:
GAVZCGTYRWKKDV-UHFFFAOYSA-N
InChI:
InChI=1S/C22H20ClN5O/c23-18-5-6-19-17(12-18)4-3-16-2-1-9-25-21(16)20(19)15-7-10-27(11-8-15)22(29)28-14-24-13-26-28/h1-2,5-6,9,12-14H,3-4,7-8,10-11H2
Canonical SMILES:
C1CC2=C(C=CC(=C2)Cl)C(=C3CCN(CC3)C(=O)N4C=NC=N4)C5=C1C=CC=N5
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CAS 1680193-80-9 JZP 361

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