JZL195 - CAS 1210004-12-8
Catalog number: 1210004-12-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), enzymes that degrade the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), the endogenous ligands for the cannabinoid G-protein coupled receptors CB1 and CB2. IC50 values are 2 nM for MAGL and 4 nM for FAAH. JZL195 has been shown to inhibit endocannabinoid hydrolysis and elevate 2-AG and AEA levels in vivo.
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JZL 195; JZL-195
1.Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model.
Adamson Barnes NS1, Mitchell VA1, Kazantzis NP1, Vaughan CW1. Br J Pharmacol. 2016 Jan;173(1):77-87. doi: 10.1111/bph.13337. Epub 2015 Dec 1.
BACKGROUND AND PURPOSE: While cannabinoids have been proposed as a potential treatment for neuropathic pain, they have limitations. Cannabinoid receptor agonists have good efficacy in animal models of neuropathic pain; they have a poor therapeutic window. Conversely, selective fatty acid amide hydrolase (FAAH) inhibitors that enhance the endocannabinoid system have a better therapeutic window, but lesser efficacy. We examined whether JZL195, a dual inhibitor of FAAH and monacylglycerol lipase (MAGL), could overcome these limitations.
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CAS 1210004-12-8 JZL195

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