JTC-801 - CAS 244218-51-7
Catalog number: 244218-51-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H25N3O2.HCl
Molecular Weight:
447.96
COA:
Inquire
Targets:
Opioid Receptor
Description:
JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and μ. It is an opioid analgesic drug used in scientific research.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
JTC-801
MSDS:
Inquire
1.Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder.
Zhang Y1, Simpson-Durand CD, Standifer KM. Br J Pharmacol. 2015 Jan;172(2):571-82. doi: 10.1111/bph.12701. Epub 2014 Jul 1.
BACKGROUND AND PURPOSE: Single-prolonged stress (SPS), a rat model of post-traumatic stress disorder (PTSD), also induces long-lasting hyperalgesia associated with hypocortisolism and elevated nociceptin/orphanin FQ (N/OFQ) levels in serum and CSF. Here, we determined the effect of JTC-801 (N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl) benzamide monohydrochloride), a nociceptin/orphanin FQ peptide (NOP) receptor antagonist, on symptoms of pain and anxiety in rats after SPS exposure, and examined N/OFQ-NOP receptor system changes.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Opioid Receptor Products


CAS 115199-84-3 ICI 199,441 hydrochloride

ICI 199,441 hydrochloride
(CAS: 115199-84-3)

ICI 199,441 hydrochloride is the hydrochloride salt of ICI 199,441, which is a selective and highly potent κ agonist. It is 146-fold more active than U-50488 in...

CAS 207452-97-9 N-MPPP Hydrochloride

N-MPPP Hydrochloride
(CAS: 207452-97-9)

N-MPPP Hydrochloride is a high affinity and selective agonist of the κ opioid receptor (KOR-1) with no measured binding at μ or δ sites.

6'-GNTI dihydrochloride

6'-GNTI dihydrochloride is a potent and selective κ/δ-opioid heterodimer receptor agonist (EC50 = 39.8, 112.5 and > 1000 nM for κ/δ, κ/μ and δ/μ, respectively) ...

CAS 1217628-73-3 SB 205607 dihydrobromide

SB 205607 dihydrobromide
(CAS: 1217628-73-3)

SB 205607 dihydrobromide is the first described non-peptide δ1 opioid receptor agonist with high affinity and selectivity for the δ1 subtype (Ki = 1.12, 2320 an...

CAS 371980-94-8 SB 612111 hydrochloride

SB 612111 hydrochloride
(CAS: 371980-94-8)

SB 612111 hydrochloride is a selective NOP receptor antagonist (Ki = 0.33, 57.6, 160.5 and 2109 nM for NOP, μ-, κ- and δ-receptors, respectively). SB 612111 exh...

CAS 89352-67-0 ICI 174,864

ICI 174,864
(CAS: 89352-67-0)

ICI 174,864 is a potent and highly selective δ opioid antagonist. It shows partial agonist in vitro activity at δ receptors at high concentrations.

CAS 58822-25-6 [Leu5]-Enkephalin

[Leu5]-Enkephalin
(CAS: 58822-25-6)

[Leu5]-Enkephalin is an endogenous opioid agonist peptide with morphine-like activity. It inhibits electrically stimulated contractions in mouse vas deferens (I...

CAS 83420-94-4 ICI 154,129

ICI 154,129
(CAS: 83420-94-4)

ICI 154,129 is a selective δ opioid antagonist. It is a peptide analog that antagonized the effects of Leu-enkephalin.

CAS 113158-35-3 Nor-Binaltorphimine dihydrochloride

Nor-Binaltorphimine dihydrochloride
(CAS: 113158-35-3)

Nor-Binaltorphimine dihydrochloride is a potent and selective kappa opioid receptor antagonist.

CAS 155512-52-0 DIPPA hydrochloride

DIPPA hydrochloride
(CAS: 155512-52-0)

DIPPA hydrochloride is an irreversible and selective antagonist of κ-opioid receptor (KOR).

CAS 34140-59-5 Trimebutine Maleate

Trimebutine Maleate
(CAS: 34140-59-5)

Trimebutine is an opioid receptor agonist used as spasmolytic agent abdominal pain.

CAS 1355244-02-8 ML 190

ML 190
(CAS: 1355244-02-8)

ML 190 is a κ opioid receptor antagonist with IC50 value of 120 nM.

CAS 78123-71-4 DAMGO

DAMGO
(CAS: 78123-71-4)

DAMGO is a highly selective peptide agonist of the μ opioid receptor.

CAS 121264-04-8 ICI 204,448 hydrochloride

ICI 204,448 hydrochloride
(CAS: 121264-04-8)

ICI 204,448 hydrochloride is the hydrochloride salt of ICI 204,448, which is a peripherally acting κ opioid receptor agonist. It does not cross the blood-brain ...

(+)-Igmesine hydrochloride
(CAS: 130152-35-1)

Igmesine is a selective σ1 receptor ligand (KD = 19.1 nM), with nearly no activity at σ2 receptors (IC50 > 1000 nM). It was developed by Pfizer. Igmesine inhibi...

CAS 103429-32-9 CTAP

CTAP
(CAS: 103429-32-9)

CTAP has been found to be a selective μ-opioid receptor antagonist.

CAS 59263-76-2 Meptazinol Hydrochloride

Meptazinol Hydrochloride
(CAS: 59263-76-2)

Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]-dihydromorphine binding with IC50 of 58 nM.

CAS 1174130-61-0 LY-2456302

LY-2456302
(CAS: 1174130-61-0)

LY-2456302, also called as CERC-501, is a potent, highly selective and centrally-penetrant kappa opioid receptor antagonist(Ki= 0.807 nM)with favorable pharmaco...

PD-117302
(CAS: 111728-01-9)

PD-117302, a new nonpeptide opioid compound, is a selective kappa-opioid agonist. It has been evaluated in vivo for antinociceptive activity and other effects c...

CAS 684238-37-7 BMS 986187

BMS 986187
(CAS: 684238-37-7)

BMS 986187 is a potent and selective δ-opioid receptor positive allosteric modulator (EC50 = 30 nM) exhibiting 100-fold selectivity for δ over μ-opioid receptor...

Chemical Structure

CAS 244218-51-7 JTC-801

Quick Inquiry

Verification code

Featured Items