JQ-1 - CAS 1268524-70-4
Catalog number:
B0084-453787
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H25ClN4O2S
Molecular Weight:
457
COA:
Inquire
Targets:
BET Bromodomain
Description:
JQ-1, a selective BET bromodomain inhibitor with antiproliferative activity, is highly active against human leukemia OCI-AML3 mutation lines such as nucleophosmin (NPM1) and DNA methyltransferase 3 (DNMT3A).Enantiomerically pure (+)-JQ1 binds to BRD4 bromodomains but the (−)-JQ1 stereoisomer has no palpable affinity to BET bromodomains.
IC 50/nM: BRD2 (N)= 17.7 ± 0.7, BRD4 (N)= 76.9 ± 1.7, BRD4 (C)= 32.6 ± 1.8;
K d/nM: BRD2 (N)= 128±6.5, BRD3 (N)= 59.5 ± 3.1, BRD3 (C)= 82.0 ±5.3, BRD4 (N)= 49.0 ± 2.4, BRD4 (C)= 90.1 ± 4.6.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-453787 50 mg $199 In stock
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Brife Description:
A selective BET bromodomain inhibitor
Appearance:
White solid
Synonyms:
(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 1,1-dimethylethyl ester; (+)-JQ1; (+)-JQ-1; (+)-JQ 1; Bromodomain Inhibitor
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -42℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Density:
1.33±0.1 g/cm3
InChIKey:
DNVXATUJJDPFDM-KRWDZBQOSA-N
InChI:
1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
Canonical SMILES:
ClC1=CC=C(C=C1)C2=N[C@@H](CC(OC(C)(C)C)=O)C3=NN=C(C)N3C4=C2C(C)=C(C)S4
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CAS 1268524-70-4 JQ-1

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