|Description||JQ-1, a selective BET bromodomain inhibitor with antiproliferative activity, is highly active against human leukemia OCI-AML3 mutation lines such as nucleophosmin (NPM1) and DNA methyltransferase 3 (DNMT3A).Enantiomerically pure (+)-JQ1 binds to BRD4 bromodomains but the (−)-JQ1 stereoisomer has no palpable affinity to BET bromodomains.
IC 50/nM: BRD2 (N)= 17.7 ± 0.7, BRD4 (N)= 76.9 ± 1.7, BRD4 (C)= 32.6 ± 1.8;
K d/nM: BRD2 (N)= 128±6.5, BRD3 (N)= 59.5 ± 3.1, BRD3 (C)= 82.0 ±5.3, BRD4 (N)= 49.0 ± 2.4, BRD4 (C)= 90.1 ± 4.6.
|B0084-453787||50 mg||$199||In stock|
|Brife Description||A selective BET bromodomain inhibitor|
|Synonyms||(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 1,1-dimethylethyl ester; (+)-JQ1; (+)-JQ-1; (+)-JQ 1; Bromodomain Inhibitor|
|Solubility||Soluble to 100 mM in DMSO and to 100 mM in ethanol|
|Storage||Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -42℃ for long term (months to years).|
|Shelf Life||2 years|
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