JNJ-42165279 - CAS 1346528-50-4
Catalog number: B0084-470836
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C18H17ClF2N4O3
Molecular Weight:
410.81
COA:
Inquire
Targets:
FAAH
Description:
JNJ-42165279 is a fatty acid amide hydrolase (FAAH) inhibitor developed by Janssen Pharmaceutica and IC50 value is 70 nM. It is described as a covalently binding but slowly reversible selective inhibitor of FAAH. Phase II human trials for the treatment of anxiety disorders and major depressive disorder is on-going.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-470836 10 mg $198 In stock
B0084-470836 25 mg $398 In stock
Bulk Inquiry
Purity:
98%
Related CAS:
1346528-52-6 (mono HCl salt); 1346528-51-5 (2HCl salt)
Appearance:
Solid powder
Synonyms:
N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine-1-carboxamide; JNJ-42165279; JNJ 42165279; JNJ42165279
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
anxiety disorders and major depressive disorder
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Gram
InChIKey:
YWGYNGCRVZLMCS-UHFFFAOYSA-N
InChI:
1S/C18H17ClF2N4O3/c19-13-3-4-22-10-14(13)23-17(26)25-7-5-24(6-8-25)11-12-1-2-15-16(9-12)28-18(20,21)27-15/h1-4,9-10H,5-8,11H2,(H,23,26)
Canonical SMILES:
O=C(N1CCN(CC2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=C(Cl)C=CN=C4
Current Developer:
Originator Janssen-Cilag
1.Preclinical Characterization of the FAAH Inhibitor JNJ-42165279.
Keith JM;Jones WM;Tichenor M;Liu J;Seierstad M;Palmer JA;Webb M;Karbarz M;Scott BP;Wilson SJ;Luo L;Wennerholm ML;Chang L;Rizzolio M;Rynberg R;Chaplan SR;Breitenbucher JG ACS Med Chem Lett. 2015 Nov 2;6(12):1204-8. doi: 10.1021/acsmedchemlett.5b00353. eCollection 2015 Dec 10.
The pre-clinical characterization of the aryl piperazinyl urea inhibitor of fatty acid amide hydrolase (FAAH) JNJ-42165279 is described. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 exhibited excellent ADME and pharmacodynamic properties as evidenced by its ability to block FAAH in the brain and periphery of rats and thereby cause an elevation of the concentrations of anandamide (AEA), oleoyl ethanolamide (OEA), and palmitoyl ethanolamide (PEA). The compound was also efficacious in the spinal nerve ligation (SNL) model of neuropathic pain. The combination of good physical, ADME, and PD properties of JNJ-42165279 supported it entering the clinical portfolio.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related FAAH Products


CAS 187947-37-1 Arachidonyl serotonin

Arachidonyl serotonin
(CAS: 187947-37-1)

Arachidonyl serotonin is a dual target agent of transient receptor potential vanilloid-type I (TRPV1) antagonist and fatty acid amide hydrolase (FAAH) inhibitor...

CAS 1346169-63-8 SA 57

SA 57
(CAS: 1346169-63-8)

SA 57 is a potent fatty acid amide hydrolase (FAAH) inhibitor (IC50 <10 nM), and also inhibits MAGL at higher concentrations (IC50 = 410 nM and 1.4 μM, respecti...

CAS 1210004-12-8 JZL195

JZL195
(CAS: 1210004-12-8)

JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), enzymes that degrade the endocannabinoids 2-arachidon...

CAS 959151-50-9 PF 750

PF 750
(CAS: 959151-50-9)

PF 750 is a potent, time-dependent, irreversible FAAH inhibitor (IC50 = 16.2 nM) that exhibits no activity at a range of other serine hydrolases. Activity-based...

CAS 1304778-15-1 TC-F 2

TC-F 2
(CAS: 1304778-15-1)

TC-F 2 is a potent, reversible and noncovalent inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 28 and 100 nM for human and rat FAAH, respectively).

CAS 326866-17-5 FAAH inhibitor 1

FAAH inhibitor 1
(CAS: 326866-17-5)

Time-dependent preincubation study of FAAH inhibitor 1 was consistent with it being a reversible inhibitor. Activity-based protein-profiling (ABPP) evaluation o...

CAS 251908-92-6 AM 1172

AM 1172
(CAS: 251908-92-6)

AM 1172, an AEA analogue, has been found to be an anandamide uptake inhibitor as well as a cannabinoid receptor partial agonist.

CAS 189939-61-5 Palmitoylisopropylamide

Palmitoylisopropylamide
(CAS: 189939-61-5)

Palmitoyl-N-isopropylamide, a synthetic analog of palmitoyl ethanolamide, is an inhibitor of the FAAH (fatty acid amide hydrolase); pIC50 = 4.89 for inhibition ...

Chemical Structure

CAS 1346528-50-4 JNJ-42165279

Quick Inquiry

Verification code

Featured Items