JNJ-42165279 - CAS 1346528-50-4
Catalog number: B0084-470836
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C18H17ClF2N4O3
Molecular Weight:
410.81
COA:
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Targets:
FAAH
Description:
JNJ-42165279 is a fatty acid amide hydrolase (FAAH) inhibitor developed by Janssen Pharmaceutica and IC50 value is 70 nM. It is described as a covalently binding but slowly reversible selective inhibitor of FAAH. Phase II human trials for the treatment of anxiety disorders and major depressive disorder is on-going.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-470836 10 mg $198 In stock
B0084-470836 25 mg $398 In stock
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Purity:
98%
Related CAS:
1346528-52-6 (mono HCl salt); 1346528-51-5 (2HCl salt)
Appearance:
Solid powder
Synonyms:
N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine-1-carboxamide; JNJ-42165279; JNJ 42165279; JNJ42165279
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
anxiety disorders and major depressive disorder
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Gram
InChIKey:
YWGYNGCRVZLMCS-UHFFFAOYSA-N
InChI:
1S/C18H17ClF2N4O3/c19-13-3-4-22-10-14(13)23-17(26)25-7-5-24(6-8-25)11-12-1-2-15-16(9-12)28-18(20,21)27-15/h1-4,9-10H,5-8,11H2,(H,23,26)
Canonical SMILES:
O=C(N1CCN(CC2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=C(Cl)C=CN=C4
Current Developer:
Originator Janssen-Cilag
1.Preclinical Characterization of the FAAH Inhibitor JNJ-42165279.
Keith JM;Jones WM;Tichenor M;Liu J;Seierstad M;Palmer JA;Webb M;Karbarz M;Scott BP;Wilson SJ;Luo L;Wennerholm ML;Chang L;Rizzolio M;Rynberg R;Chaplan SR;Breitenbucher JG ACS Med Chem Lett. 2015 Nov 2;6(12):1204-8. doi: 10.1021/acsmedchemlett.5b00353. eCollection 2015 Dec 10.
The pre-clinical characterization of the aryl piperazinyl urea inhibitor of fatty acid amide hydrolase (FAAH) JNJ-42165279 is described. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 exhibited excellent ADME and pharmacodynamic properties as evidenced by its ability to block FAAH in the brain and periphery of rats and thereby cause an elevation of the concentrations of anandamide (AEA), oleoyl ethanolamide (OEA), and palmitoyl ethanolamide (PEA). The compound was also efficacious in the spinal nerve ligation (SNL) model of neuropathic pain. The combination of good physical, ADME, and PD properties of JNJ-42165279 supported it entering the clinical portfolio.
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CAS 1346528-50-4 JNJ-42165279

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