JNJ-42041935 - CAS 1193383-09-3
Catalog number: 1193383-09-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
HIF/HIF Prolyl-Hydroxylase
JNJ-42041935 is a potent (pK(I) = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. JNJ-42041935 is a new pharmacological tool, which can investigate PHD inhibition and demonstrate that PHD inhibitors offer great promise for the treatment of inflammation-induced anemia.
Publictions citing BOC Sciences Products
  • >> More
Solid powder
JNJ-42041935; JNJ 42041935; JNJ42041935.
Soluble in DMSO, not in water
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life:
2 years if stored properly
Canonical SMILES:
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related HIF/HIF Prolyl-Hydroxylase Products

CAS 327-97-9 Chlorogenic Acid

Chlorogenic Acid
(CAS: 327-97-9)

Chlorogenic acid is a hydroxycinnamic acid and a member of a family of naturally occurring organic compounds.

CAS 808118-40-3 Roxadustat (FG-4592)

Roxadustat (FG-4592)
(CAS: 808118-40-3)

Roxadustat (FG-4592) is an HIF α prolyl hydroxylase inhibitor, stabilizes HIF-2 and induces EPO production.

(CAS: 223387-75-5)

FG-2216, also known as YM311, is orally bioavailable HIF-prolyl hydroxylase inhibitor. FG-2216 induced significant and reversible Epo induction in vivo.

(CAS: 1193383-09-3)

JNJ-42041935 is a potent (pK(I) = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. JNJ-42041935 is a new pharmacologica...

CAS 89464-63-1 DMOG

(CAS: 89464-63-1)

DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase.

(CAS: 960539-70-2)

Daprodustat, also known as GSK1278863, is a novel HIF-prolyl hydroxylase inhibitor. Hypoxia inducible factor (HIF) stabilization by HIF-prolyl hydroxylase (PHD)...

CAS 1227946-51-1 HIF Phd Inhibitor 4

HIF Phd Inhibitor 4
(CAS: 1227946-51-1)

An inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD).

CAS 64224-21-1 Oltipraz

(CAS: 64224-21-1)

Oltipraz, a promising cancer chemopreventive agent, is a bifunctional inducer, modulating both phase I and II drug-metabolizing enzymes to enhance carcinogen de...

(CAS: 62054-67-5)

THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings.

CAS 1403-36-7 Chetomin

(CAS: 1403-36-7)

Chetomin is a natural metabolite produced by several species of the genus chaetomium. It is an epidithiodioxopiperazine and is an inhibitor of hypoxia-inducible...

CAS 1446322-66-2 TAT-cyclo-CLLFVY

(CAS: 1446322-66-2)

TAT-cyclo-CLLFVY has been found to be a HIF-1 dimerization inhibitor and could block protein-protein interaction of recombinant HIF-1α.

CAS 1227158-85-1 BAY 87-2243

BAY 87-2243
(CAS: 1227158-85-1)

BAY 87-2243 inhibits HIF-1 reporter gene activity and CA9 protein expression with IC50 of 0.7 nM and 2 nM, respectively.

CAS 931398-72-0 IOX2

(CAS: 931398-72-0)

CAS 1187990-87-9 MK-8617

(CAS: 1187990-87-9)

MK-8617 is a potent and selective pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3) (PHD1: IC50 = 1.0 nM; PHD2: IC50 =1.0nM; PHD3: I...

(CAS: 1672665-49-4)

PT-2385 is a small molecule inhibitor with oral activity that inhibits hypoxia inducible factor (HIF)-2alpha heterodimerization and its subsequent binding to DN...

CAS 685898-44-6 PX-478

(CAS: 685898-44-6)

PX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. Although its mechanism of action has yet to be ...

CAS 1357171-62-0 ML228

(CAS: 1357171-62-0)

HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of i...

CAS 385786-48-1 Adaptaquin

(CAS: 385786-48-1)

Adaptaquin is an inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase 2 (PHD2) with IC50 value of 2 μM in a reporter assay using SH-SY5Y-ODD-Luc cells...

CAS 1422955-31-4 TC-S 7009

TC-S 7009
(CAS: 1422955-31-4)

TC-S 7009 is a high affinity and selective HIF-2α inhibitor (Kd = 81 nM) that displays >60-fold selectivity for HIF-2α over HIF-1α. TC-S 7009 binds to the HIF-2...

CAS 1154028-82-6 Molidustat

(CAS: 1154028-82-6)

Molidustat, also known as BAY 85-3934, is a novel inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) which stimulates erythropoietin (EPO) prod...

Quick Inquiry

Verification code

Featured Items