JNJ-41443532 - CAS 1228650-83-6
Catalog number: 1228650-83-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H25F3N4O3S
Molecular Weight:
482.52
COA:
Inquire
Targets:
CCR
Description:
This active molecular is a CCR2 receptor antagonist which is applicated for the treatment of type-2 diabetes mellitus under the development of Janssen Research & Development. In 2010, Phase-I clinical trials in Type-2 diabetes mellitus was on-going. in Belgium and USA.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Powder
Synonyms:
N-(2-((1-(trans-4-hydroxy-4-(5-thiazolyl)cyclohexyl)-3-azetidinyl)amino)-2-oxoethyl)-3-(trifluoromethyl)Benzamide
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
type-2 diabetes mellitus
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
CFKBNYUHQSQBSX-CYWCHRQTSA-N
InChI:
1S/C22H25F3N4O3S/c23-22(24,25)15-3-1-2-14(8-15)20(31)27-10-19(30)28-16-11-29(12-16)17-4-6-21(32,7-5-17)18-9-26-13-33-18/h1-3,8-9,13,16-17,32H,4-7,10-12H2,(H,27,31)(H,28,30)/t17-,21-
Canonical SMILES:
c1cc(cc(c1)C(=O)NCC(=O)NC2CN(C2)[C@H]3CC[C@@](CC3)(O)c4scnc4)C(F)(F)F
Current Developer:
Janssen Research & Development
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related CCR Products


CAS 1341224-83-6 PF-4136309

PF-4136309
(CAS: 1341224-83-6)

Potent, selective, and orally bioavailable CCR2 antagonist

CAS 353791-85-2 J 113863

J 113863
(CAS: 353791-85-2)

Potent CCR1 antagonist

CAS 300815-41-2 RS102895

RS102895
(CAS: 300815-41-2)

Potent and specific CCR2 antagonist with binding IC50 of 360 nM

CAS 106362-34-9 DAPTA

DAPTA
(CAS: 106362-34-9)

CCR5 antagonist

CAS 1173022-16-6 RS 102895 hydrochloride

RS 102895 hydrochloride
(CAS: 1173022-16-6)

CCR2b antagonist

CAS 376348-65-1 Maraviroc

Maraviroc
(CAS: 376348-65-1)

Selective CCR5 antagonist

CAS 288262-96-4 BX471 hydrochloride

BX471 hydrochloride
(CAS: 288262-96-4)

Potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1)

CAS 887401-93-6 INCB 3284 dimesylate

INCB 3284 dimesylate
(CAS: 887401-93-6)

Potent, selective and orally bioavailable CCR2 antagonist with IC50 of 3.7 nM.

CAS 1226894-87-6 YJC-10592

YJC-10592
(CAS: 1226894-87-6)

YJC-10592 is a CC chemokine receptor 2 (CCR2) antagonist (IC50 value 1.12 μM).

CAS 217645-70-0 BX 471

BX 471
(CAS: 217645-70-0)

Selective CCR1 antagonist

CAS 566203-88-1 AZD 2098

AZD 2098
(CAS: 566203-88-1)

AZD 2098 is a potent and selective CCR4 receptor antagonist (pIC50 = 7.8) used for the treatment of allergic rhinitis. CCR4 is a molecule that can drive the imm...

Teijin compound 1
(CAS: 1313730-14-1)

Potent CCR2b antagonist

CAS 1780259-94-0 ZK756326 (dihydrochloride)

ZK756326 (dihydrochloride)
(CAS: 1780259-94-0)

ZK756326 is a selective and nonpeptide chemokine receptor agonist for the CC chemokine receptor CCR8 (IC50= 1.8 muM).

JNJ-41443532
(CAS: 1228650-83-6)

This active molecular is a CCR2 receptor antagonist which is applicated for the treatment of type-2 diabetes mellitus under the development of Janssen Research ...

CAS 874911-96-3 ZK 756326

ZK 756326
(CAS: 874911-96-3)

Selective, non-peptide CCR8 agonist

CAS 247580-43-4 SB 328437

SB 328437
(CAS: 247580-43-4)

Potent and selective CCR3 antagonist

CAS 624733-88-6 MK-0812

MK-0812
(CAS: 624733-88-6)

Potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes

CAS 300816-15-3 RS 504393

RS 504393
(CAS: 300816-15-3)

Highly selective CCR2 antagonist

CP-481715
(CAS: 212790-31-3)

CP-481715 is a potent and selective CCR1 antagonist with >100-fold selective for CCR1 as compared with a panel of G-protein-coupled receptors including related ...

Vercirnon
(CAS: 698394-73-9)

Highly potent antagonist of CCR9

Quick Inquiry

Verification code

Featured Items