JLK 6 - CAS 62252-26-0
Catalog number:
62252-26-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C10H8ClNO3
Molecular Weight:
225.63
COA:
Inquire
Targets:
γ-secretase
Description:
JLK 6, under the IUPAC name 7-amino-4-chloro-3-methoxyisochromen-1-one, an inhibitor of γ-secretase (IC50= between 10 μM-1 mM) that belongs to the class of isocoumarin analogs, prevents recovery of Aβ40 and Aβ42 (IC50 < 100 µM) in HEK293 cells overexpressing wild-type and Swedish-mutant β-amyloid precursor protein (APP).
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Brife Description:
An inhibitor of γ-secretase (IC50= between 10 μM-1 mM)
Appearance:
Yellow solid
Synonyms:
7-amino-4-chloro-3-methoxyisochromen-1-one; 7-Amino-4-chloro-3-methoxyisocoumarin; jlk6; 62252-26-0; JLK 6; 7-Amino-4-chloro-3-methoxy-isocoumarin; gamma-Secretase Inhibitor XI; 7-amino-4-chloro-3-methoxyisochromen-1-one; AC1L1GQZ; AC1Q3FXG; JLK-6; CHEMBL149518; SCHEMBL3056620; CTK2F1888; AMDGKLWVCUXONP-UHFFFAOYSA-N; HMS3269N03; ZINC2523036; AR-1H3136; ZINC02523036; 7-amino-3-methoxy-4-chloroisocoumarin; AKOS024457236; NCGC00167827-01; AK396360; HE005374; HE366264; TX-017351; 7-Amino-4-chloro-3-methoxy-isochromen-1-one; 7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one; 1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy-; BRD-K22010301-001-01-2; JLK 6|7-Amino-4-chloro-3-methoxy-1H-2-benzopyran; JLK 6; 7-AMINO-4-CHLORO-3-METHOXY-1H-2-BENZOPYRAN
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -26℃ for long term (months to years).
MSDS:
Inquire
Boiling Point:
456.1℃ at 760 mmHg
Melting Point:
173-175℃
Density:
1.46 g/cm3
InChIKey:
AMDGKLWVCUXONP-UHFFFAOYSA-N
InChI:
1S/C10H8ClNO3/c1-14-10-8(11)6-3-2-5(12)4-7(6)9(13)15-10/h2-4H,12H2,1H3
Canonical SMILES:
COC1=C(C2=C(C=C(C=C2)N)C(=O)O1)Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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Chemical Structure

CAS 62252-26-0 JLK 6

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