|Description||Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling. It is an inhibitor of Smo and derived from the Veratrum plant species. Jervine can be used to induce abnormal morphogenesis in a number of experimental models.|
RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.
HPI 1 is a hedgehog (Hh) signaling inhibitor that blocks Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 = 1.5, 1.5,...
Glasdegib is an orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway that binds to Smoothened (Smo) and inhibits signal transduct...
Vismodegib (GDC-0449) is a potent, novel and specific inhibitor of hedgehog with IC50 of 3 nM and also inhibitor of P-gp with IC50 of 3.0 μM.
U 18666A is a cell-permeable and amphiphilic amino-steroid that inhibits cholesterol synthesis and cellular transport via the suppression of 2,3-oxidosqualene-l...
Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling. It is an inhibitor of Smo and derived from th...
AY 9944 dihydrochloride
AY 9944 dihydrochloride is the dihydrochloride salt of AY 9944, which is an amphiphilic and cell-permeable diamine and acts as a sonic hedgehog inhibitor. It ma...
Ciliobrevin A is a Hedgehog (HH) pathway inhibitor and is a key signaling molecule in HH pathway. It blocked HH pathway activation by SAG, decreased Smo ciliary...
SAG 21k is a potent, brain penetrating and orally available activator of Hedgehog signaling (EC50 = 0.4 nM).
RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase) (IC50 = 0.85 µM). RU-SKI 43 is cell-permeable and inhibits both autocrine and paracrin...
AZ 12080282 dihydrochloride is the dihydrochloride salt of AZ 12080282, which is a novel hedgehog antagonist and inhibits towards the SMO receptor affecting emb...
NL-103, a nicotinamide derivative, has been found to be an inhibitor of both histone deacetylases and hedgehog pathway. It was found to exhibit activity in decr...