|Targets||Amyloid-β | Others|
|Description||J 147, under the IUPAC name N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide, a phenyl hydrazide compound that has been shown to prevent memory deficits in an Alzheimer’s disease mouse model. in vitro: A potent neuroprotective and neurotrophic compound (EC50 = 25 - 200 nM) in vivo: Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus|
|B0084-462708||25 mg||$199||In stock|
|Brife Description||A potent neuroprotective and neurotrophic compound (in vitro: EC50 = 25 - 200 nM)|
|Synonyms||J147; J 147; J-147. N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide; J-147; 1146963-51-0; N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide; CHEMBL2387144; SCHEMBL12995834; 3752AH; AKOS024458485; CS-3688; AK279964; BC600735; HY-13779; 2,2,2-Trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene]hydrazide; J 147|2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide|
|Solubility||Soluble to 100 mM in DMSO and to 100 mM in ethanol|
|Storage||Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -37℃ for long term (months to years).|
|Application||Implicated in Alzheimer's disease|
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