|Description||IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM.|
|B0084-262341||25 mg||$198||In stock|
LF3 is a potent inhibitor of Wnt/β-catenin signaling (IC50= 1.65 μM), but does not interfere with E-cadherin/β-catenin-mediated cell-cell adhesion.antitumor act...
KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.
Heparan sulfate, a complex and linear polysaccharide in which the backbone is composed of repeating sulfated disaccharide units, exists as part of glycoproteins...
The hydrochloride salt form of AMBMP, which has been found to be a Wnt canonical signaling activator and could probably be effective in the treatment of muscle ...
SKL 2001 is a Wnt/β-catenin signaling pathway agonist that modulates the differentiation of mesenchumal stem cells. It upregulates the β-catenin responsive tran...
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling. It is thought to directly influence the interaction...
CCT251545, a small molecule inhibitor of WNT signaling with oral activity, can be used as a selective chemical probe that exhibits >100-fold selectivity for the...
Foxy 5 is a Wnt signaling pathway modulator used for the treatment of metastatic breast cancer, prostate cancer and colorectal cancer. It impairs migration and ...
NSC-668036 is a Wnt signaling inhibitor, binding to the PDZ domain of the dishevelled protein. It can inhibit proliferation, migration and TGF-β-induced differe...
XAV 939 is a tankyrase (TNKS) inhibitor with IC50 values of 11 nM and 4 nM for tankyrase 1 and 2 respectively. XAV 939 antagonizes Wnt signaling via stimulation...
KY1220 is a novel inhibitor of the Wnt/ß-catenin pathway, destabilizing both β-catenin and Ras via targeting the Wnt/β-catenin pathway (IC50= 2.1 μM in HEK293 r...
JW 67 has been found to be a new antagonist of canonical Wnt signaling and exhibit activities in restraining growth and downregulated Wnt target genes in human ...
WAY 262611 dihydrochloride is an inhibitor of Dickkopf-1 (DKK1), which antagonizes Wnt/β-Catenin signaling. DKK1 is a soluble inhibitor of Wnt-3a mediated Wnt/β...
NCB-0846 is an orally available, first-in-class TNIK inhibitor (IC50= 21 nM) and shows marked anti-tumour and anti-CSC activities.
ETC-159, also known as ETC-1922159, is a potent, selective and orally available PORCN inhibitor. ETC-159 blocks the secretion and activity of all Wnts.
KYA1797K is a potent, selective and dual inhibitor of Wnt/β-catenin (IC50= 0.75 µM) that significantly decreases reporter activities for the Wnt/β-catenin and M...
IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM.
exo-IWR 1, the enantiomer of IWR-1 and the diastereomer of IWR-1-endo, is a potent SAR anticancer Wnt response inhibitor, which is a kind of small secreted prot...
PRI-724 is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling pathwa...
FH535 sodium salt is a dual inhibitor of peroxisome proliferator-activated receptor (PPAR) and Wnt/β-catenin/TCF/LEF signaling. FH535 inhibits recruitment of th...