|Description||IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM.|
|B0084-262341||25 mg||$198||In stock|
Pyrvinium pamoate, a nonabsorbed anthelmintic drug, is a potent androgen receptor inhibitor and a selective WNT pathway inhibitor. Pyrvinium pamoate is a potent...
NCB-0846 is an orally available, first-in-class TNIK inhibitor (IC50= 21 nM) and shows marked anti-tumour and anti-CSC activities.
KY1220 is a novel inhibitor of the Wnt/ß-catenin pathway, destabilizing both β-catenin and Ras via targeting the Wnt/β-catenin pathway (IC50= 2.1 μM in HEK293 r...
XAV 939 is a tankyrase (TNKS) inhibitor with IC50 values of 11 nM and 4 nM for tankyrase 1 and 2 respectively. XAV 939 antagonizes Wnt signaling via stimulation...
KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.
PRI-724 is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling pathwa...
The hydrochloride salt form of AMBMP, which has been found to be a Wnt canonical signaling activator and could probably be effective in the treatment of muscle ...
IQ-1, a cell-permeable tetrahydroisoquinolinylidene compound, disrupts Wnt signaling that enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spon...
CCT251545, a small molecule inhibitor of WNT signaling with oral activity, can be used as a selective chemical probe that exhibits >100-fold selectivity for the...
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling. It is thought to directly influence the interaction...
WAY 262611 dihydrochloride is an inhibitor of Dickkopf-1 (DKK1), which antagonizes Wnt/β-Catenin signaling. DKK1 is a soluble inhibitor of Wnt-3a mediated Wnt/β...
WIKI4 is a novel inhibitor of tankyrase and Wnt/ß-catenin signaling. WIKI4 inhibits expression of ß-catenin target genes and cellular responses to Wnt/ß-catenin...
JW 67 has been found to be a new antagonist of canonical Wnt signaling and exhibit activities in restraining growth and downregulated Wnt target genes in human ...
Cardionogen 1 has been found to be a Wnt signaling modulator that could affect cardiomyocyte generation.
SKL 2001 is a Wnt/β-catenin signaling pathway agonist that modulates the differentiation of mesenchumal stem cells. It upregulates the β-catenin responsive tran...
LF3 is a potent inhibitor of Wnt/β-catenin signaling (IC50= 1.65 μM), but does not interfere with E-cadherin/β-catenin-mediated cell-cell adhesion.antitumor act...
Foxy 5 is a Wnt signaling pathway modulator used for the treatment of metastatic breast cancer, prostate cancer and colorectal cancer. It impairs migration and ...
Adavivint is a Wnt pathway inhibitor.
NSC-668036 is a Wnt signaling inhibitor, binding to the PDZ domain of the dishevelled protein. It can inhibit proliferation, migration and TGF-β-induced differe...
Heparan sulfate, a complex and linear polysaccharide in which the backbone is composed of repeating sulfated disaccharide units, exists as part of glycoproteins...