|Description||IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM.|
|B0084-262341||25 mg||$198||In stock|
NCB-0846 is an orally available, first-in-class TNIK inhibitor (IC50= 21 nM) and shows marked anti-tumour and anti-CSC activities.
Heparan sulfate, a complex and linear polysaccharide in which the backbone is composed of repeating sulfated disaccharide units, exists as part of glycoproteins...
FH535 sodium salt is a dual inhibitor of peroxisome proliferator-activated receptor (PPAR) and Wnt/β-catenin/TCF/LEF signaling. FH535 inhibits recruitment of th...
IQ-1, a cell-permeable tetrahydroisoquinolinylidene compound, disrupts Wnt signaling that enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spon...
XAV 939 is a tankyrase (TNKS) inhibitor with IC50 values of 11 nM and 4 nM for tankyrase 1 and 2 respectively. XAV 939 antagonizes Wnt signaling via stimulation...
Adavivint is a Wnt pathway inhibitor.
CCT251545, a small molecule inhibitor of WNT signaling with oral activity, can be used as a selective chemical probe that exhibits >100-fold selectivity for the...
PRI-724 is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling pathwa...
KY1220 is a novel inhibitor of the Wnt/ß-catenin pathway, destabilizing both β-catenin and Ras via targeting the Wnt/β-catenin pathway (IC50= 2.1 μM in HEK293 r...
Cardionogen 1 has been found to be a Wnt signaling modulator that could affect cardiomyocyte generation.
LF3 is a potent inhibitor of Wnt/β-catenin signaling (IC50= 1.65 μM), but does not interfere with E-cadherin/β-catenin-mediated cell-cell adhesion.antitumor act...
Foxy 5 is a Wnt signaling pathway modulator used for the treatment of metastatic breast cancer, prostate cancer and colorectal cancer. It impairs migration and ...
WAY 262611 dihydrochloride is an inhibitor of Dickkopf-1 (DKK1), which antagonizes Wnt/β-Catenin signaling. DKK1 is a soluble inhibitor of Wnt-3a mediated Wnt/β...
KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.
KYA1797K is a potent, selective and dual inhibitor of Wnt/β-catenin (IC50= 0.75 µM) that significantly decreases reporter activities for the Wnt/β-catenin and M...
The hydrochloride salt form of AMBMP, which has been found to be a Wnt canonical signaling activator and could probably be effective in the treatment of muscle ...
BML-284 is potent selective, and cell-permeable Wnt signaling activator that does not inhibit GSK-3β (IC50 > 60 µM). It appears to mimic the effects of a Wnt li...
IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM.
JW 67 has been found to be a new antagonist of canonical Wnt signaling and exhibit activities in restraining growth and downregulated Wnt target genes in human ...
NSC-668036 is a Wnt signaling inhibitor, binding to the PDZ domain of the dishevelled protein. It can inhibit proliferation, migration and TGF-β-induced differe...