|Description||This active molecular is a scavenger receptor B1 antagonist under the development by iTherX Pharmaceuticals for the treatment of Hepatitis C. ITX-5061 shows a special mechanism of action that prevents the hepatitis C virus from entering liver cells. Preclinical studies have shown that ITX-5061 can prevent virus binding/fusion and cell to cell spread. In Jan 2015, Phase-II clinical trials in Hepatitis C in USA was on-going.|
|Synonyms||UNII-J4RA8K2Q2A; J4RA8K2Q2A;CHEMBL3402567;N-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide;hydrochloride;848144-15-0 (free base)|
|Solubility||Soluble in DMSO|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||iTherX Pharmaceuticals|
Heparin sodium is a sodium salt of heparin which is a naturally-occurring anticoagulant used for anticoagulation for cardiovascular disease. It is an inhibitor ...
Ginsenoside Rg3 is a natural product isolated from Panax ginseng. Similar to other ginsenosides it exhibits cardio protective effects. Ginsenoside Rg3 enhances ...
β-Apo-13-carotenone, also known as D'Orenone, a naturally occurring β-apocarotenoid, is an antagonist of RXRα.
Danshensu is an active component of Salvia miltiorrhiza that shows wide cardiovascular benefit. It suppresses the formation of reactive oxygen species and inhib...
Evans Blue is a potent inhibitor of L-glutamate uptake into synaptic vesicles and is able to antagonize AMPA (IC50=220 nM) and kainate receptor (IC50=150 nM) me...
Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties.
Acroteben is a bio-active chemical but no detailed information has been published yet.
Efloxate, a flavone derivative, could be effective in the treatment of chronic coronary insufficiency and angina pectoris for acting as a vasodilator.
Glafenine hydrochloride, an anthranilic acid derivative, is a non-narcotic analgesic and non-steroidal anti-inflammatory drug. It is an ABCG2 inhibitor (IC50= 3...
ITX3 is a specific inhibitor of endogenous TrioN activity acting on the GEF domain and selective cell active inhibitor of the Trio/RhoG/Rac1 pathway. The compou...
Astragaloside II is a saponin found in the root of Astragalus membranaceus (Fisch.) Bunge, which is known as huáng qí in Traditional Chinese Medicine. It has ca...
This active molecular can be applicated as a photosensitizer for PDT (Photodynamic Therapy) of cancer. Redaporfin showed a great efficacy in the treatment of ma...
Amitraz is a non-systemic acaricide and insecticide, as an antiparasitic used to control red spider mites, leaf miners and scale insects.
Docosatrienoic acid is a rare ω-3 fatty acid, not readily detected in normal phospholipid PUFA pools. Docosatrienoic acid inhibits LTB4 binding to pig neutrophi...
Duloxetine metabolite Para-Naphthol Dulo
Duloxetine metabolite Para-Naphthol Duloxetine is a metabolite of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor.
BMS711939 is a selective and potent peroxisome proliferator-activated receptor α(PPARα) agonist with EC50 value of 4 nM for human PPARα. It is >1000-fold select...
Namiteca is a new water-soluble camptothecin analogue as a hydrophilic camptothecin with a promising preclinical profile.
BMS-505130 is a selective serotonin transport inhibitor with Ki of 0.18 nM. Ki value for binding to the norepinephrine is 4.6 mM and for dopamine transporters i...
CB 3988 is a bio-active chemical compound.
NAI-N3 is a novel RNA acylation reagent that enables RNA purification.