Itraconazole - CAS 84625-61-6
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Not Intended for Therapeutic Use. For research use only.
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Itraconazole, a triazole antifungal agent, is a relatively potent inhibitor of CYP3A4.
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1.Antifungal susceptibility patterns of a global collection of fungal isolates: results of the SENTRY Antifungal Surveillance Program (2013).
Castanheira M1, Messer SA2, Rhomberg PR2, Pfaller MA3. Diagn Microbiol Infect Dis. 2016 Feb 9. pii: S0732-8893(16)30010-4. doi: 10.1016/j.diagmicrobio.2016.02.009. [Epub ahead of print]
Among 1846 fungal clinical isolates from 31 countries, echinocandin resistance in Candida spp. ranged from 0.0% to 2.8% (highest for anidulafungin versus Candida glabrata), and fluconazole resistance was noted among 11.9% and 11.6% of the C. glabrata and Candida tropicalis, respectively. Two isolates of Aspergillus fumigatus displayed elevated MICs for itraconazole and carried cyp51a mutations encoding TR34 L98H. All Cryptococcus neoformans had azole MIC values below epidemiological cutoff values. The increasing resistance among certain species and more frequent reports of breakthrough infections in patients undergoing antifungal therapy highlights the importance of antifungal surveillance to guide therapy for patients with invasive fungal infections.
2.Peel bond strength of soft lining materials with antifungal to a denture base acrylic resin.
Sánchez-Aliaga A1, Pellissari CV, Arrais CA, Michél MD, Neppelenbroek KH, Urban VM. Dent Mater J. 2016;35(2):194-203. doi: 10.4012/dmj.2014-269.
The effect of the addition of nystatin, miconazole, ketoconazole, chlorhexidine, and itraconazole into the soft lining materials Softone and Trusoft on their peel bond strength to a denture base acrylic resin was evaluated. Specimens of soft lining materials (n=7) were made without (control) or with the incorporation of antifungals at their minimum inhibitory concentrations to the biofilm of C. albicans and bonded to the acrylic resin. Peel testing was performed after immersion in distilled water at 37ºC for 24 h, 7 and 14 days. Data (MPa) were analyzed by 3-way ANOVA/Tukey-Kramer test (α=0.05) and the failure modes were classified. The addition of nystatin and ketoconazole did not affect the peel bond strength for up to 14 days. Most failures were predominantly cohesive within soft lining materials. With the exception of itraconazole, incorporating the antifungals into the soft lining materials did not result in values below those recommended for peel bond strength after 7 and 14 days of analysis.
3.Controlled Inactivation of Trichophyton rubrum Using Shaped Electrical Pulse Bursts: Parametric Analysis.
Novickij V1, Grainys A1, Švedienė J2, Paškevičius A2,3, Novickij J1. Biotechnol Prog. 2016 Apr 12. doi: 10.1002/btpr.2276. [Epub ahead of print]
The dermatophytes infect the skin by adherence to the epidermis followed by germination, growth and penetration of the fungal hyphae within the cells. The aim of this study was to investigate the efficacy of the pulsed electric fields (PEF) of controlled inactivation of Trichophyton rubrum (ATCC 28188). In this work we have used bursts of the square wave PEF pulses of different intensity (10-30 kV/cm) to induce the irreversible inactivation in vitro. The electric field pulses of 50 µs and 100 µs have been generated in bursts of 5, 10 and 20 pulses with repetition frequency of 1 Hz. The dynamics of the inactivation using different treatment parameters were studied and the inactivation map for the T. rubrum has been defined. Further, the combined effect of pulsed electric fields with the antifungal agents itraconazole, terbinafine and naftifine HCl was investigated. It has been demonstrated that the combined effect results in the full inactivation of T.
4.Phaeohyphomycosis infection in the knee.
Sadigursky D1, Nogueira E Ferreira L1, Moreno de Oliveira Corrêa L1. Rev Bras Ortop. 2016 Feb 23;51(2):231-4. doi: 10.1016/j.rboe.2016.02.004.
in English, PortugueseA feohifomicose, causada por fungos demáceos, raramente acomete grandes articulações. Este é um relato de caso de feohifomicose, em joelho esquerdo de idoso não imunossuprimido, acompanhado de dor e aumento de volume em região anterior do joelho. Suspeitou-se de bursite suprapatelar, sendo medicado com anti-inflamatório não esteroidal, sem apresentar remissão dos sintomas. Fez-se tratamento cirúrgico, foram ressecadas a bursa suprapatelar e a região anterior do tendão do quadríceps sendo a peça encaminhada para exame anatomopatológico e cultura. No exame anatomopatológico foi possível evidenciar o diagnóstico de feohifomicose. O tratamento instituído foi itraconazol, 200 mg/dia por seis semanas, apresentando remissão completa do quadro. O exame físico se manteve normal após um ano de seguimento. Este é o primeiro caso publicado a respeito da infecção por feohifomicose em região suprapatelar. Apesar de quase todos os casos registrados estarem associados a pacientes imunossuprimidos, este foi uma exceção.
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CAS 84625-61-6 Itraconazole

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