Itacitinib - CAS 1334298-90-6
Catalog number:
1334298-90-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H23F4N9O
Molecular Weight:
553.51
COA:
Inquire
Targets:
JAK
Description:
Itacitinib is a potent Janus kinase-1 inhibitor under the development of AstraZeneca and Incyte Corporation. Itacitinib can inhibit OCT2-mediated uptake of creatinine as well as MATE1-/MATE2-K-mediated efflux of creatinine. Now it is in Phase II trials for the treatment of Graft-versus-host disease; Non-small cell lung cancer.
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Purity:
98%
Appearance:
Powder
Synonyms:
INCB 039110;2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile
Solubility:
DMSO: > 35 mg/Ml
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Graft-versus-host disease; Non-small cell lung cancer
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
KTBSXLIQKWEBRB-UHFFFAOYSA-N
InChI:
1S/C26H23F4N9O/c27-20-18(1-7-32-22(20)26(28,29)30)24(40)37-9-3-17(4-10-37)38-13-25(14-38,5-6-31)39-12-16(11-36-39)21-19-2-8-33-23(19)35-15-34-21/h1-2,7-8,11-12,15,17H,3-5,9-10,13-14H2,(H,33,34,35)
Canonical SMILES:
Fc1c(ccnc1C(F)(F)F)C(=O)N2CCC(CC2)N3CC(CC#N)(C3)n4cc(cn4)c5ncnc6[nH]ccc56
Current Developer:
AstraZeneca; Incyte Corporation
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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