IT1t dihydrochloride - CAS 1092776-63-0
Catalog number:
1092776-63-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H34N4S2.2HCl
Molecular Weight:
479.57
COA:
Inquire
Targets:
CXCR
Description:
Potent CXCR4 antagonist(IC50 = 1.1 nM in calcium mobilization assays); Orally available
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
Potent CXCR4 antagonist(IC50 = 1.1 nM in calcium mobilization assays); Orally available
Appearance:
Off-White Solid
Synonyms:
N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride; IT1t; IT1t dihydrochloride
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store at +4°C
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
InChI:
1S/C21H34N4S2/c1-21(2)15-25-18(14-27-20(25)24-21)13-26-19(22-16-9-5-3-6-10-16)23-17-11-7-4-8-12-17/h14,16-17H,3-13,15H2,1-2H3,(H,22,23)
Canonical SMILES:
CC1(C)N=C2SC=C(CS/C(NC3CCCCC3)=N\C4CCCCC4)N2C1.[H]Cl.[H]Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related CXCR Products


CAS 1873376-49-8 CXCR2-IN-1

CXCR2-IN-1
(CAS: 1873376-49-8)

CXCR2-IN-1 is a CXCR2 antagonists (pIC50= 9.3) with favorable central nervous system penetration property (Br/Bl>0.45).

CAS 558447-26-0 AMD-070

AMD-070
(CAS: 558447-26-0)

Potent and selective antagonist of CXCR4 (with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay)

AMD 3465
(CAS: 185991-24-6)

AMD 3465,a N-pyridinylmethylene monocyclam, is a selective antagonist of CXCL12/CXCR4-mediated interactions including ligand binding and receptor activation. Wi...

Danirixin
(CAS: 954126-98-8)

A small molecule, non-peptide CXCR2 antagonist; High affinity (IC50 for CXCL8 binding = 12.5 nM), selective, and reversible

CAS 911715-90-7 AZD8797

AZD8797
(CAS: 911715-90-7)

AZD8797 is a selective allosteric non-competitive modulator of the human CX3CR1 receptor (Ki= 3.9 nM), binding CX3CR1 and effecting<br/>G-protein signalling and...

CAS 55778-02-4 WZ 811

WZ 811
(CAS: 55778-02-4)

Potent CXCR2 antagonist

CAS 113558-15-9 Baohuoside I

Baohuoside I
(CAS: 113558-15-9)

A regulator of CXCR4 expression

SB 332235
(CAS: 276702-15-9)

Potent CXCR2 antagonist

KRH3955
(CAS: 1097732-62-1)

KRH3955 is a novel CXCR4 antagonist. It is an orally bioavailable compound. It inhibits SDF-1alpha-mediated chemotaxis and HIV-1 infection.

CTCE 9908
(CAS: 1030384-98-5)

CXCR4 antagonist; Induces mitotic catastrophe in ovarian cancer cells

IT1t dihydrochloride
(CAS: 1092776-63-0)

Potent CXCR4 antagonist(IC50 = 1.1 nM in calcium mobilization assays); Orally available

CAS 1986-81-8 Nicotinamide N-oxide

Nicotinamide N-oxide
(CAS: 1986-81-8)

Nicotinamide N-oxide, a metabolite of Nicotinamide, is a potent, and selective antagonist of the CXCR2 receptor and used in studies of mechanisms of niacin-rela...

CAS 473727-83-2 SCH 527123

SCH 527123
(CAS: 473727-83-2)

A potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively.

Navarixin
(CAS: 862464-58-2)

Navarixin is a potent CXC chemokine receptor 2 (CXCR2) antagonist. It can be used for the treatment of Asthma and Chronic obstructive pulmonary disease. In Dec ...

FC 131
(CAS: 606968-52-9)

CXCR4 antagonist

VUF 11222
(CAS: 1414376-84-3)

High affinity non-peptide CXCR3 agonist (pKi = 7.2)

KRH1636
(CAS: 568526-77-2)

KRH1636 is an orally active, selective and extremely potent CXC chemokine receptor 4(CXCR4) antagonist. It exhibits a potent and selective anti-HIV-1 activity. ...

CAS 185991-07-5 AMD3465 hexahydrobromide

AMD3465 hexahydrobromide
(CAS: 185991-07-5)

AMD3465 is a potent and highly selective monomacrocyclic CXCR4 antagonist (IC50= 0.75 nM). It potently inhibits HIV cell entry in vitro and causes leukocytosis ...

CAS 906805-42-3 SCH 546738

SCH 546738
(CAS: 906805-42-3)

A novel, potent and non-competitive small molecule CXCR3 antagonist with Ki of 0.4 nM

CAS 956590-23-1 UNBS5162

UNBS5162
(CAS: 956590-23-1)

A novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers

Quick Inquiry

Verification code

Featured Items