Isovitexin - CAS 29702-25-8
Catalog number: 29702-25-8
Not Intended for Therapeutic Use. For research use only.
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1.Molecular targets of vitexin and isovitexin in cancer therapy: a critical review.
Ganesan K;Xu B Ann N Y Acad Sci. 2017 Aug;1401(1):102-113. doi: 10.1111/nyas.13446.
Cancer is a primary public health problem and the second leading cause of death worldwide. It causes life-threatening malignancies and results in high financial costs for both patients and the healthcare system. Hence, it is important to develop effective long-term strategies pertaining to prevention and control of cancers. Plant-derived secondary metabolites have been shown to have positive roles against various cancers. A number of plant extracts have been evaluated for possible use in the treatment of cancer; some have provided direction for new strategies for the research and development of antitumor agents. Here, we provide comprehensive data on various cancers, potential molecular mechanisms, and therapeutic implications of just two plant-derived compounds, vitexin and isovitexin. Information on the chemotherapeutic potential of vitexin and isovitexin was collected from a library database and through electronic searches (ScienceDirect, Pubmed, and Google Scholar).
2.[Chemical Components from Leaves of Fatsia japonica and Their Antitumor Activities in vitro].
Wei Q;Qiu Z;Xu F;Li QR;Yin H Zhong Yao Cai. 2015 Apr;38(4):745-50.
OBJECTIVE: ;To study the chemical components from the leaves of Fatsia japonica and their antitumor activities in vitro.;METHODS: ;All compounds were separated and purified by column chromatography over silica gel, Sephadex LH-20 and preparative HPLC. Their structures were identified by physical and chemical properties and spectral methods including 1H-NMR and 13C-NMR. Antitumor assay was measured by MTT method.;RESULTS: ;18 compounds were isolated and identified as palmitic acid (1), β-hydroxypropiovanillone (2), adenosine (3), β-sitosterol (4), daucosterol (5), oleanolic acid (6), echinocystic acid (7), betulinic acid (8), hederagenin(9), hederagenin-3-O-α-L-rhamnopyranosyl(1-->2)-α-L-arabinopyranoside(10), acacetin(11), quercetin(12), quercetin-3-O-β-D-glucopyranoside(13), isovitexin(14), isovitexin-7-O-glucoside(15), astragalin(16), methylpluviatolide(17), and syringaresinol-4-O-β-D-glucopyranoside(18).;CONCLUSION: ;All compounds are isolated from the leaves of Fatsia japonica for the first time except compound 1.
3.Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin.
Choi JS;Islam MN;Ali MY;Kim EJ;Kim YM;Jung HA Food Chem Toxicol. 2014 Feb;64:27-33. doi: 10.1016/j.fct.2013.11.020. Epub 2013 Nov 27.
Apigenin has gained particular interests in recent years as a beneficial and health promoting agent because of its low intrinsic toxicity. Vitexin and isovitexin, naturally occurring C-glycosylated derivatives of apigenin, have been known to possess potent anti-diabetic, anti-Alzheimer's disease (anti-AD), and anti-inflammatory activities. The present study was designed to investigate the anti-diabetic, anti-AD, and anti-inflammatory potential of apigenin and its two C-glycosylated derivatives, vitexin and isovitexin by in vitro assays including rat lens aldose reductase (RLAR), human recombinant aldose reductase (HRAR), advanced glycation endproducts (AGEs), protein tyrosine phosphatase 1B (PTP1B), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), β-site amyloid precursor (APP) cleaving enzyme 1 (BACE1), and nitric oxide (NO), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced RAW 264.
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