|Description||Isotretinoin, also known as 13-cis retinoic acid and first marketed as Accutane by Hoffmann-La Roche, is an oral pharmaceutical drug primarily used to treat cystic acne.It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.|
|Synonyms||13-cis retinoic acid|
LG 100268 is a retinoid X receptor agonist with EC50 value of 4 nM. It can inhibit vinyl carbamate-induced lung tumor growth in mice in vivo.
LY 2955303 hydrochloride is a potent and selective retinoic acid receptor gamma (RARγ) antagonist (Ki values >1700 nM, >2980 nM, and 1.1 nM for RARα, RARβ, and ...
CD 2314 is a potent and selective RARβ receptor agonist (Kd = 145 and >3760 nM for RARβ and RARα receptors, respectively).
BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist that enhances interaction of nuclear corepressor (NCoR) and RARs.
BMS 961 is a potent and selective RARγ agonist (EC50 = 30 and 1000 nM at RARγ and RARβ, respectively) displaying no activity at RARα receptors. It was found tha...
AC 55649 is a potent and isoform-selective RARβ2 receptor agonist (pEC50 = 6.9, 5.7 and 5.6 at RARβ2, RARβ1 and RARα, respectively). It causes inhibition of pro...
LG 100754 is a RXR:PPARγ agonist. It can decrease glucose levels and relieve insulin resistance in mice. LG 100754 shows antidiabetic properties in vivo.
Fluorobexarotene is a RXR agonist (Ki = 12 nM; EC50 = 43 nM at RXRα receptors).
LG 101506 is a selective RXR modulator.
MM 11253 is a RARγ antagonist. It can block the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells.
Fenretinide is an orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenreti...
Acitretin is a second generation retinoid used for psoriasis.
AGN 205728 is a potent and selective RARγ antagonist and has no inhibiton on RARα and RARβ.
CD 2665 is a selective RARβ and RARγ antagonist (KD = 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively) with no activity at RXRα. CD 2665 is used to ...
UAB30 is a low-toxicity retinoid X receptor-selective agonist selective for the binding and activation of RXR’s over RAR' s. UAB30 is highly effective in the pr...
Isotretinoin, also known as 13-cis retinoic acid and first marketed as Accutane by Hoffmann-La Roche, is an oral pharmaceutical drug primarily used to treat cys...
AC 261066 is a potent RARβ2 agonist (pEC50 = 8.1).
HX 630 is a potent RXR agonist that acts as a retinoid synergist. HX 630 suppresses proliferation of vascular smooth muscle cells (VSMCs) in vivo and in vitro. ...
CD 3254 is a selective RXRα agonist with no activity at RARα, RARβ or RARγ receptors.
Acitretin sodium is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. It can be considered one of the treatments of choic...