Isotretinoin - CAS 4759-48-2
Catalog number: 4759-48-2
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H28O2
Molecular Weight:
300.44
COA:
Inquire
Targets:
RAR/RXR
Description:
Isotretinoin, also known as 13-cis retinoic acid and first marketed as Accutane by Hoffmann-La Roche, is an oral pharmaceutical drug primarily used to treat cystic acne.It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
Purity:
>98%
Synonyms:
13-cis retinoic acid
MSDS:
Inquire
InChIKey:
SHGAZHPCJJPHSC-WBBXYVSWSA-N
InChI:
InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11-,15-8+,16-14+
Canonical SMILES:
CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
1.Presenile diffuse familial sebaceous hyperplasia successfully treated with low-dose isotretinoin: A report of two cases and review of the published work.
Liu YS1,2, Cheng YP2,3,4, Liu CI2, Yang CI5, Yang CY2,3. J Dermatol. 2016 Apr 30. doi: 10.1111/1346-8138.13416. [Epub ahead of print]
Presenile diffuse familial sebaceous hyperplasia (PDFSH) presents as extensive yellowish papules with central umbilication on the face without involvement of periorificial regions and occurs in adolescents or young adults with a positive family history. Thirteen cases of PDFSH have been reported in the English-language published work, 10 of which responded to oral isotretinoin from 0.5 to 1 mg/kg per day but recurrences were often observed. Herein, we report two cases of PDFSH, which were successfully managed without recurrence with prolonged low-dose isotretinoin (0.2 mg/kg per day, a cumulative dose of 41 and 64 mg/kg, respectively). Treatment protocols among different published works were reviewed to verify the efficacy of isotretinoin.
2.Pro-inflammatory sebocyte growth and survival signaling in acne vulgaris is reversed by pro-apoptotic isotretinoin signaling.
Melnik BC1. Exp Dermatol. 2016 Apr 20. doi: 10.1111/exd.13032. [Epub ahead of print]
Since the introduction of isotretinoin for the treatment of severe forms acne, it took nearly four decades to understand isotretinoin's mode of action, which is related to the drug's sebum suppressive effect (s1,s2). Isotretinoin-induced sebum reduction depends primarily on sebocyte apoptosis (1,2,s3). Decreased FoxO1 activity in sebocytes of acne patients and increased mechanistic target of rapamycin complex 1 (mTORC1) activity in lesional skin of acne patients promote excessive sebum production and dysseborrhea activating the NLRP3 inflammasome (3-6, s4). This article is protected by copyright. All rights reserved.
3.Occurrence of pregnancy and pregnancy outcomes during isotretinoin therapy.
Henry D, Dormuth C, Winquist B, Carney G, Bugden S, Teare G, Lévesque LE, Bérard A, Paterson JM, Platt RW. CMAJ. 2016 Apr 25. pii: cmaj.151243. [Epub ahead of print]
BACKGROUND: Isotretinoin, a teratogen, is widely used to treat cystic acne. Although the risks of pregnancy during isotretinoin therapy are well recognized, there are doubts about the level of adherence with the pregnancy prevention program in Canada. Our objective was to evaluate the effectiveness of the Canadian pregnancy prevention program in 4 provinces: British Columbia, Saskatchewan, Manitoba and Ontario.
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CAS 4759-48-2 Isotretinoin

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