|Description||Isotretinoin, also known as 13-cis retinoic acid and first marketed as Accutane by Hoffmann-La Roche, is an oral pharmaceutical drug primarily used to treat cystic acne.It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.|
|Synonyms||13-cis retinoic acid|
ER 50891 is an RARα receptor antagonist (IC50 = 31.2 nM).
Adapalene sodium salt
Adapalene sodium salt, a synthetic retinoid, is a Retinoic acid receptor agonist (RAR). It is a third-generation topical retinoid primarily used in the treatmen...
RX-195183 is an RARα agonist (Kd=3 nM) with potential antineoplastic activity, modulating the transcription of genes responsible for cell differentiation and pr...
NRX-204647 is a Retinoic acid receptor gamma-selective inverse agonist.
HX-603 is a RXR agonist.
BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist that enhances interaction of nuclear corepressor (NCoR) and RARs.
CD 3254 is a selective RXRα agonist with no activity at RARα, RARβ or RARγ receptors.
LE 135 is a retinoic acid antagonist which shows moderate selectivity for RARβ over RARα. It can inhibit human HL-60 leukemia cell differentiation induced by Am...
Palovarotene is a selective retinoic acid receptor gamma(RAR-γ) agonist for the treatment of emphysema. In small animal studies, palovarotene was claimed to rev...
Acitretin sodium is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. It can be considered one of the treatments of choic...
PA 452 is a RXR antagonist. It can attenuate cell proliferation and induce apoptosis in MCF-7 breast cancer cells.
BMS 961 is a potent and selective RARγ agonist (EC50 = 30 and 1000 nM at RARγ and RARβ, respectively) displaying no activity at RARα receptors. It was found tha...
LY2955303 is a selective Retinoic acid receptor gamma (RAR-γ) antagonist with Ki of 1.09 nM; (RAR-α Ki > 1700 nM; RAR-β Ki > 2980 nM). LY2955303 showed good pha...
Fenretinide is an orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenreti...
LG 100754 is a RXR:PPARγ agonist. It can decrease glucose levels and relieve insulin resistance in mice. LG 100754 shows antidiabetic properties in vivo.
TTNPB potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARα, RARβ, and RARγ, respectively). And it does not act on reti...
LG 100268 is a retinoid X receptor agonist with EC50 value of 4 nM. It can inhibit vinyl carbamate-induced lung tumor growth in mice in vivo.
SR 11237 is a pan retinoid X receptor (RXR) agonist with no RAR activity.
LG 101506 is a selective RXR modulator.
Adapalene is more active than indomethacin, betamethasone valerate, tretinoin, isotretinoin or etretinate in inhibiting lipoxygease activity, but it has little ...