Isosorbide mononitrate - CAS 16051-77-7
Catalog number: 16051-77-7
Category: Inhibitor
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Molecular Formula:
C6H9NO6
Molecular Weight:
191.14
COA:
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Targets:
Others
Description:
A coronary vasodilator that does not require hepatic biotransformation
Purity:
>98%
Synonyms:
AHR 4698; AHR-4698; BM 22-145; BM 22.145; BRN 5851319; CCRIS 1911; Isosorbide Mononitrate. trade name Monoket, Imdur, Monosorb, Chemydur. Isosorbide-5-mononitrate
MSDS:
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InChIKey:
YWXYYJSYQOXTPL-SLPGGIOYSA-N
InChI:
InChI=1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5+,6+/m0/s1
Canonical SMILES:
C1C(C2C(O1)C(CO2)O[N+](=O)[O-])O
1.Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction.
Redfield MM1, Anstrom KJ, Levine JA, Koepp GA, Borlaug BA, Chen HH, LeWinter MM, Joseph SM, Shah SJ, Semigran MJ, Felker GM, Cole RT, Reeves GR, Tedford RJ, Tang WH, McNulty SE, Velazquez EJ, Shah MR, Braunwald E; NHLBI Heart Failure Clinical Research Net N Engl J Med. 2015 Dec 10;373(24):2314-24. doi: 10.1056/NEJMoa1510774. Epub 2015 Nov 8.
BACKGROUND: Nitrates are commonly prescribed to enhance activity tolerance in patients with heart failure and a preserved ejection fraction. We compared the effect of isosorbide mononitrate or placebo on daily activity in such patients.
2.Intra-arterial vasodilators to prevent radial artery spasm: a systematic review and pooled analysis of clinical studies.
Kwok CS1, Rashid M2, Fraser D3, Nolan J4, Mamas M5. Cardiovasc Revasc Med. 2015 Dec;16(8):484-90. doi: 10.1016/j.carrev.2015.08.008. Epub 2015 Aug 15.
OBJECTIVES: The aim of this study is to review the available literature on the efficacy and safety of agents used for prevention of RAS.
3.Towards a pragmatic human migraine model for drug testing: 2. Isosorbide-5-mononitrate in healthy individuals.
Hansen EK1, Olesen J2. Cephalalgia. 2016 Feb 27. pii: 0333102416636095. [Epub ahead of print]
BACKGROUND: A model for the testing of novel anti-migraine drugs should preferably use healthy volunteers for ease of recruiting. Isosorbide-5-mononitrate (5-ISMN) provokes headache in healthy volunteers with some migraine features such as pulsating pain quality and aggravation by physical activity. Therefore, this headache might respond to sumatriptan, a requirement for validation of any model. The hypothesis of the present study was that sumatriptan is effective in 5-ISMN-induced headache in healthy individuals.
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CAS 16051-77-7 Isosorbide mononitrate

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