Isosorbide - CAS 652-67-5
Catalog number: 652-67-5
Category: Inhibitor
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Molecular Formula:
C6H10O4
Molecular Weight:
146.14
COA:
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Targets:
Others
Description:
Isosorbide is a heterocyclic compound that is derived from glucose, used as a diuretic.
Purity:
>98%
Synonyms:
Isosorbide; Devicoran; Hydronol; Ismotic; Isobide;
MSDS:
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InChIKey:
KLDXJTOLSGUMSJ-JGWLITMVSA-N
InChI:
InChI=1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1
Canonical SMILES:
C1C(C2C(O1)C(CO2)O)O
1.Moderate vasomotor response to acetylcholine provocation test as an indicator of long-term prognosis.
Hoshino M1, Yonetsu T2, Mizukami A2, Matsuda Y2, Yoshioka K2, Sudo Y2, Ninomiya R2, Soeda M2, Kuroda S2, Ono M2, Iwatsuka R2, Suzuki M2, Matsumura A2, Hashimoto Y2. Heart Vessels. 2016 Mar 11. [Epub ahead of print]
The acetylcholine (ACh) provocation test (ACh-test) is used for the diagnosis of vasospastic angina (VSA). However, subjects often show a moderate spasm (MS) response for which diagnosis of VSA is not definitive, and the clinical significance of this response is unknown. We assessed moderate coronary vasomotor response to the ACh test as an indicator of long-term prognosis. A total of 298 consecutive patients who underwent the ACh test for suspected VSA were retrospectively investigated. Coronary spasm severity after intracoronary administration of isosorbide dinitrate was evaluated by measuring epicardial coronary artery diameter reduction after ACh injection. Patients were divided into three groups according to the diameter reduction during the ACh test: severe spasm (SS) showing ≥75 % diameter reduction, MS showing ≥50 % diameter reduction, and others (N). In Kaplan-Meier analysis, the major adverse cardiac event (MACE) rates with a median follow-up of 4.
2.Short Flow-Photochemistry Enabled Synthesis of the Cytotoxic Lactone (+)-Goniofufurone.
Ralph M1, Ng S2, Booker-Milburn KI1. Org Lett. 2016 Mar 4;18(5):968-71. doi: 10.1021/acs.orglett.6b00067. Epub 2016 Feb 18.
A photochemical approach to the cytotoxic lactone (+)-goniofufurone (1) is reported. Paternò-Büchi [2 + 2] photocycloaddition from known enol ether 4, derived from the readily available sugar d-isosorbide, yielded oxetane 7. This slow, dilute reaction was scaled up by using flow photochemistry to yield >40 g of 7. Installation of the key lactone ring was achieved via a unique Wacker-style oxidation of an enol-ether bond. Acid-catalyzed aqueous ring opening provided 1 in five steps from 4 (11.5% overall).
3.Repeated Dosing with NCX1404, a Nitric Oxide-Donating Pregabalin, Re-establishes Normal Nociceptive Responses in Mice with Streptozotocin-Induced Painful Diabetic Neuropathy.
Varani K1, Vincenzi F1, Targa M1, Ravani A1, Bastia E1, Storoni L1, Brambilla S1, Almirante N1, Impagnatiello F2. J Pharmacol Exp Ther. 2016 May;357(2):240-7. doi: 10.1124/jpet.115.230193. Epub 2016 Feb 23.
NCX1404 [(3S)-5-methyl-3-(((1-(4-(nitrooxy)butanoyloxy)ethoxy)carbonylamino) methyl)hexanoic acid] is a novel nitric oxide (NO)-donating pregabalin that is readily absorbed and processed in vivo to pregabalin and NO. We determined the antiallodynic response of NCX1404 after acute or after 7, 14, and 21 days of repeated daily oral dosing in mice with streptozotocin (STZ)-induced painful diabetic neuropathy (PDN). Pregabalin and its combination with the NO donor isosorbide mononitrate (ISMN) were used for comparison. The blood levels of pregabalin and nitrites, used as surrogate marker of NO release, after NCX1404 or pregabalin dosing were monitored in parallel experiments using liquid chromatography with tandem mass spectrometry (LC-MS/MS). NCX1404 and pregabalin resulted in similar pregabalin levels as it was their antiallodynic activity after acute dosing in STZ mice. However, NCX1404 resulted in disease-modifying properties when administered daily for 21 days, as indicated by the time- and dose-dependent reversal of STZ-induced mechanical allodynia (paw withdrawal threshold [PWT]Veh_21d= 1.
4.Combination of Bioactive Polymeric Membranes and Stem Cells for Periodontal Regeneration: In Vitro and In Vivo Analyses.
Gonçalves F1, de Moraes MS2, Ferreira LB3, Carreira AC4, Kossugue PM4, Boaro LC3, Bentini R1, Garcia CR2, Sogayar MC4,5, Arana-Chavez VE3, Catalani LH1. PLoS One. 2016 Mar 31;11(3):e0152412. doi: 10.1371/journal.pone.0152412. eCollection 2016.
Regeneration of periodontal tissues requires a concerted effort to obtain consistent and predictable results in vivo. The aim of the present study was to test a new family of bioactive polymeric membranes in combination with stem cell therapy for periodontal regeneration. In particular, the novel polyester poly(isosorbide succinate-co-L-lactide) (PisPLLA) was compared with poly(L-lactide) (PLLA). Both polymers were combined with collagen (COL), hydroxyapatite (HA) and the growth factor bone morphogenetic protein-7 (BMP7), and their osteoinductive capacity was evaluated via in vitro and in vivo experiments. Membranes composed of PLLA/COL/HA or PisPLLA/COL/HA were able to promote periodontal regeneration and new bone formation in fenestration defects in rat jaws. According to quantitative real-time polymerase chain reaction (qRT-PCR) and Alizarin Red assays, better osteoconductive capacity and increased extracellular mineralization were observed for PLLA/COL/HA, whereas better osteoinductive properties were associated with PisPLLA/COL/HA.
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CAS 652-67-5 Isosorbide

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