Isopsoralen - CAS 523-50-2
Catalog number: 523-50-2
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C11H6O3
Molecular Weight:
186.2
COA:
Inquire
Targets:
Others
Description:
Angelicin is a furanocoumarin isolated from P. corylifolia might be a potential new agent for prevention of inflammatory reactions.
Purity:
≥98%
Appearance:
White Solid
Synonyms:
Angelicin; 2H-Furo[2,3-H]chromen-2-one; Furo[2,3-h]chromen-2-one
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Immunomodulatory
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Melting Point:
132-134˚C
InChIKey:
XDROKJSWHURZGO-UHFFFAOYSA-N
InChI:
1S/C11H6O3/c12-10-4-2-7-1-3-9-8(5-6-13-9)11(7)14-10/h1-6H
Canonical SMILES:
C1=CC2=C(C=CO2)C3=C1C=CC(=O)O3
1.Mechanism-based inactivation of cytochrome P450 2B6 by isopsoralen.
Lu D1, Ji L1, Zheng L1, Cao J1, Peng Y1, Zheng J2,3. Xenobiotica. 2016 Apr;46(4):335-41. doi: 10.3109/00498254.2015.1077403. Epub 2015 Sep 4.
1. Isopsoralen (IPRN) is a major component in many traditional medicinal herbs widely used in Asian countries. The objective of the present study was to investigate the inhibitory effect of IPRN on cytochrome P450 2B6 (CYP2B6) and the mechanism involved in the enzyme inactivation. 2. Pre-incubation of CYP2B6 with IPRN resulted in a time- and concentration-dependent enzyme activity loss. The values of KI and kinact were found to be 7.89 μM and 0.067 min(-1), respectively. Ticlopidine exhibited protective effect on the IPRN-induced enzyme inactivation. The estimated partition ratio of the inactivation was 122. The GSH trapping experiments indicate that an epoxide and/or γ-ketoenal intermediate were/was generated in IPRN-fortified microsomal incubations. The synthetic work verified the formation of the reactive intermediate(s). Additionally, CYPs2E1, 2C19, 2B6 and 1A2 were found to be the major enzymes participating in the bioactivation of IPRN.
2.Evaluation of the influence of salt processing on pharmacokinetics of psoralen and isopsoralen in Psoralea corylifolia L.
Gao QQ1, Yan CP2, Xu ZS3, Wu Y4, Weng ZB1, Zhao GH1, Zhang LJ1, He JY1, Cai BC1, Chen ZP1, Li WD1. Biomed Chromatogr. 2016 Apr;30(4):528-35. doi: 10.1002/bmc.3578. Epub 2015 Sep 11.
A sensitive, specific and rapid ultra-high-pressure liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method has been developed to investigate pharmacokinetic properties of psoralen and isopsoralen, two compounds isolated from raw/salt-processed fruit of Psoralea corylifolia L. UHPLC-MS/MS was used with positive ion electrospray. The mobile phase was composed of acetonitrile and 0.1% formic acid aqueous solution and a gradient elution program at flow rate of 0.3 mL/min was applied. Multiple reaction monitoring mode was used for the quantification of psoralen, isopsoralen ([M + H](+) m/z 187.0 → m/z 131.0) and scoparone (m/z 207.0 → m/z 151.1). Scoparone served as an internal standard. The method was fully validated for its sensitivity, selectivity, stability, matrix effect and extraction recovery. The obtained results showed that salt-processed Buguzhi significantly promoted the absorption of psoralen and isopsoralen, and increased the bioavailability of these compounds.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 1235481-90-9 P7C3-A20

P7C3-A20
(CAS: 1235481-90-9)

P7C3-A20, an analogue of P7C3, is a neuroprotective compound which inhibits mature neuronal cell death while also increasing the net magnitude of postnatal neur...

CAS 62936-56-5 pikamilone sodium

pikamilone sodium
(CAS: 62936-56-5)

Pikamilone sodium is a prodrug of GABA that is used in the treatment of benign prostatic hyperplasia and neurogenic bladder in spinal.

CAS 33171-05-0 Bisdemethoxycurcumin

Bisdemethoxycurcumin
(CAS: 33171-05-0)

Bisdemethoxycurcumin is one of the three major forms of curcuminoids found in the rhizomes of turmeric. Bisdemethoxycurcumin displays antioxidant, anti-inflamma...

CAS 1044589-82-3 NITD 008

NITD 008
(CAS: 1044589-82-3)

NITD008 is a flavivirus inhibitor. It was developed as a potential treatment for flavivirus infections, and shows broad spectrum antiviral activity.

CAS 465-90-7 Hellebrigenin

Hellebrigenin
(CAS: 465-90-7)

Hellebrigenin is an anticancer agent that induces DNA damage, mitochondria collapse, cell cycle arrest and apoptosis.

Protease-Activated Receptor-4

Protease-Activated Receptor-4, a member of the PARs family, is activated by thrombin, trypsin and cathepsin G but also is the agonist o fproteinase-activated re...

CAS 143982-31-4 LY 186564

LY 186564
(CAS: 143982-31-4)

LY 186564 is a bio-active chemical,but no detailed information has been published yet.

CAS 739-71-9 trimipramine

trimipramine
(CAS: 739-71-9)

Trimipramine is a tricyclic antidepressant. It is serotonin and norepinephrine transport inhibitor with antipsychotic and sedative properties.

Chemical Structure

CAS 523-50-2 Isopsoralen

Quick Inquiry

Verification code

Featured Items