Isopropylantipyrinum - CAS 479-92-5
Catalog number:
479-92-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C14H18N2O
Molecular Weight:
230.31
COA:
Inquire
Targets:
Others
Description:
Isopropylantipyrinum is a derivative of phenazone with similar analgesic and antipyretic effects.
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Purity:
≥98%
Appearance:
White Solid
Synonyms:
Propyphenazone; 1,2-Dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one; 1-Phenyl-2,3-dimethyl-4-isopropyl-3-pyrazolin-5-one;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Analgesic; antipyretic; anti-inflammatory.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Melting Point:
88-90 °C
InChIKey:
PXWLVJLKJGVOKE-UHFFFAOYSA-N
InChI:
1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3
Canonical SMILES:
CC1=C(C(=O)N(N1C)C2=CC=CC=C2)C(C)C
1.Effects of prenatal exposure to combination of acetaminophen, isopropylantipyrine and caffeine on intrauterine development in rats.
Burdan F1. Hum Exp Toxicol. 2002 Jan;21(1):25-31.
The common effects of acetaminophen (paracetamol), isopropylantipyrine (propyphenazone) and caffeine on fetal development were examined in rats. The mixture was given in Tween 80 solution once daily, in a constant proportion of 5:3:1, during days 8-14 of gestation in three different doses. Dose S1 - 3.5 mg/kg acetaminophen, 2.14 mg/kg isopropylantipyrine, 0.7 mg/kg caffeine. Dose S2 was 10 times higher, and S3 100 times higher than dose S1. On day 21 of gestation, the dams were sacrificed and the fetuses were removed. The corpora lutea, resorptions, live and dead fetuses were counted. The pre- and postimplantation mortality were calculated. The weight of fetuses and placentas, and the length of fetuses and their tails were measured. Two-thirds of each litter was processed for Alizarin Red S staining. The remaining third was fixed in Bouin's solution for subsequent visceral examination by using modified Wilson's technique. A significant decrease in body weight in S1 group, and fetal length and placental weight in group S3 were recorded.
2.Formation of the knee joint after prenatal propyphenazone (isopropylantipyrine) administration.
Burdan F1. Cells Tissues Organs. 2002;171(2-3):145-51.
Cyclooxygenase (COX) inhibitors could produce cartilage toxicity as well as delayed skeleton formation when administrated during pregnancy. The purpose of this experiment was to determine the effect of a nonselective COX inhibitor, propyphenazone (isopropylantipyrine), on the development of the knee joint in rats. The drug was administered orally in Tween 80 water suspension once a day on days 8-14 of gestation in three doses: R1: 2.1 mg/kg, R2: 21.0 mg/kg and R3: 210.0 mg/kg. Two control groups were formed: untreated control (K) and Tween 80-treated (T) animals. Fetuses were delivered by cesarean section on day 21 of gestation and examined macroscopically for external malformations. The knee joints of two fetuses of each litter were sectioned in situ or paraffin-embedded. The slides were examined microscopically. The remaining fetuses were stained using the Alcian blue and red S alizarin skeleton double-staining method. Reduced alizarin staining in bones from the knee joint, and wider epiphysial cartilage was seen in 2 of 53 examined fetuses (3.
3.Clinical features of immediate hypersensitivity to isopropylantipyrine.
Hwang EK1, Nam YH, Jin HJ, Shin YS, Ye YM, Park HS. Allergy Asthma Immunol Res. 2013 Jan;5(1):55-8. doi: 10.4168/aair.2013.5.1.55. Epub 2012 Aug 29.
Hypersensitivities induced by isopropylantipyrine (IPA), a pyrazolone derivative within the wider family of non-steroidal anti-inflammatory drugs (NSAIDs), are rarely reported. We characterized the clinical features of 12 patients with IPA-induced hypersensitivity. Twelve patients with immediate hypersensitivity to IPA were enrolled and classified into two groups: group I, consisting of eight patients (66.7%) with selective hypersensitivity; and group II, consisting of four patients (33.3%) showing cross-intolerance to other NSAIDs. Skin prick and intradermal and oral provocation tests with IPA were performed. To confirm selective hypersensitivity, an aspirin oral provocation test was also conducted. The most common manifestations were cutaneous reactions (91.7%), followed by anaphylaxis (66.7%), respiratory (41.7%), ocular (16.7%), and gastrointestinal reactions (16.7%). The median age and the median age at onset were 34.5 (range, 23-55) years and 28.
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CAS 479-92-5 Isopropylantipyrinum

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