Isoprenaline HCl - CAS 51-30-9
Catalog number: B0084-350898
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H17NO3.HCl
Molecular Weight:
247.72
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Isoprenaline is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block. It would increase cAMP levels and activate protein kinase A and ERK1/2 through its effect on β-adrenoceptor.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-350898 50 g $279 In stock
Bulk Inquiry
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
beta-adrenergic receptor agonist, bradycardia and heart block
Purity:
>98%
Synonyms:
NCI-c55630; Aerolone; Aerotrol; 4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol, hydrochloride
MSDS:
Inquire
Application:
the treatment of bradycardia and heart block
InChIKey:
IROWCYIEJAOFOW-UHFFFAOYSA-N
InChI:
InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
Canonical SMILES:
CC(C)NCC(C1=CC(=C(C=C1)O)O)O.Cl
1.Isoproterenol directs hair follicle-associated pluripotent (HAP) stem cells to differentiate in vitro to cardiac muscle cells which can be induced to form beating heart-muscle tissue sheets.
Yamazaki A1, Yashiro M1, Mii S1, Aki R1, Hamada Y1, Arakawa N1, Kawahara K2,3, Hoffman RM4,5, Amoh Y1. Cell Cycle. 2016 Mar 3;15(5):760-5. doi: 10.1080/15384101.2016.1146837.
Nestin-expressing hair-follicle-associated pluripotent (HAP) stem cells are located in the bulge area of the follicle. Previous studies have shown that HAP stem cells can differentiate to neurons, glia, keratinocytes, smooth muscle cells, and melanocytes in vitro. HAP stem cells effected nerve and spinal cord regeneration in mouse models. Recently, we demonstrated that HAP stem cells differentiated to beating cardiac muscle cells. The differentiation potential to cardiac muscle cells was greatest in the upper part of the follicle. The beat rate of the cardiac muscle cells was stimulated by isoproterenol. In the present study, we observed that isoproterenol directs HAP stem cells to differentiate to cardiac muscle cells in large numbers in culture compared to HAP stem cells not supplemented with isoproterenol. The addition of activin A, bone morphogenetic protein 4, and basic fibroblast growth factor, along with isoproternal, induced the cardiac muscle cells to form tissue sheets of beating heart muscle cells.
2.ECL cells involvement in the isoproterenol-induced gastroprotection. An ultrastructural study.
Dabroś W1, Brzozowski T, Konturek SJ, Stachura J. Pol J Pathol. 1998;49(1):3-13.
The central and peripheral adrenergic systems are involved in the regulation of several functions in the gut including the maintenance of gastric microcirculation and gastric secretion but little is known about the role of the adrenergic system, in particular, beta-adrenoceptors in the phenomenon of gastroprotection. In this study acute gastric lesions were provoked by an intragastric (i.g.) application of 100% ethanol in rats with topical application of isoproterenol (ISO) (1 mg/kg) or subcutaneous (s.c.) administration of ranitidine (RAN) (40 mg/kg) or both. An area of gastric lesions was determined by planimetry, gastric blood flow (GBF) was determined by H2-gas clearance technique and gastric specimens were taken for histology and electron microscopy. It was found that ISO reduced ethanol-induced gastric mucosal lesions and this effect was accompanied by a rise in GBF. In contrast, RAN applied s.c. in a dose that produced almost complete achlorhydria, failed to affect ethanol-lesions but attenuated significantly ISO induced gastroprotection and abolished the increase in the GBF induced by this beta-adrenoceptor agonist.
3.Prolonged isoproterenol infusion impairs the ability of beta(2)-agonists to increase alveolar liquid clearance.
Morgan EE1, Hodnichak CM, Stader SM, Maender KC, Boja JW, Folkesson HG, Maron MB. Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L666-74.
We determined if prolonged isoproterenol (Iso) infusion in rats impaired the ability of the beta(2)-adrenergic agonist terbutaline to increase alveolar liquid clearance (ALC). We infused rats with Iso (at rates of 4, 40, or 400 microg.kg(-1).h(-1)) or vehicle (0.001 N HCl) for 48 h using subcutaneously implanted miniosmotic pumps. After this time, the rats were anesthetized, and ALC was determined (by mass-balance after instillation of Ringer lactate containing albumin into the lungs) under baseline conditions and after terbutaline administration. Baseline and terbutaline-stimulated ALC in vehicle-infused rats averaged, respectively, 19.6 +/- 1.2% (SE) and 44.7 +/- 1.5%/h. The ability of terbutaline to increase ALC was eliminated at 400 microg.kg(-1).h(-1)Iso, inhibited by 26% at 40 microg.kg(-1).h(-1) Iso, and was not affected by 4 microg.kg(-1).h(-1) Iso. beta-adrenergic receptor (betaAR) density of freshly isolated alveolar epithelial type II (ATII) cells from Iso-infused rats was reduced by the 40 and 400 microg.
4.Antioxidant effects of hydroxysafflor yellow A and acetyl-11-keto-β-boswellic acid in combination on isoproterenol-induced myocardial injury in rats.
Chen M1, Wang M1, Yang Q1, Wang M2, Wang Z2, Zhu Y1, Zhang Y1, Wang C1, Jia Y1, Li Y1, Wen A1. Int J Mol Med. 2016 Apr 20. doi: 10.3892/ijmm.2016.2571. [Epub ahead of print]
Oxidative stress plays an important role in the initiation and development of myocardial injury (MI). The peroxisome proliferator-activated receptor gamma coactivator-1α (PGC‑1α)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is considered to be a potential target for cardioprotection in MI. Acetyl-11-keto-β-boswellic acid (AKBA) is the major organic acid component extracted from Boswellia serrata Roxb. ex Colebr. Hydroxysafflor yellow A (HSYA) is the principal active constituent of Carthamus tinctorius L. In the present study, we aimed to investigate the cardioprotective effects of HSYA and AKBA in combination in vivo and in vitro, as well as the underlying mechanisms responsible for these effects. For this purpose, MI was produced in Sprague-Dawley rats by subcutaneous injection with isoproterenol. To model ischemic-like conditions in vitro, H9C2 cells were subjected to oxygen-glucose deprivation (OGD). The levels of creatine kinase-MB (CK‑MB), lactate dehydrogenase (LDH), malondialdehyde (MDA) as well as superoxide dismutase (SOD) activity were examined as well as apoptotic cell death.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Adrenergic Receptor Products


CAS 21498-08-8 Lofexidine hydrochloride

Lofexidine hydrochloride
(CAS: 21498-08-8)

Lofexidine hydrochloride is the hydrochloride salt form of Lofexidine. Lofexidine, an analogue of clonidine, is an α2A-adrenergic receptor agonist for the treat...

CAS 90038-01-0 Detomidine HCl

Detomidine HCl
(CAS: 90038-01-0)

Detomidine is a selective α2-adrenoceptor agonist (Ki = 1.62 nM) that binds to α1-adrenoceptors with much weaker potency (Ki = 415 nM).

CAS 63659-18-7 Betaxolol

Betaxolol
(CAS: 63659-18-7)

Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.

CAS 62929-91-3 Procaterol hydrochloride

Procaterol hydrochloride
(CAS: 62929-91-3)

Procaterol hydrochloride is a long-acting, very potent and specific beta-2-adrenergic receptor agonist. It acts as a vasodialator for long term treatment of ast...

CAS 849-55-8 Nylidrin hydrochloride

Nylidrin hydrochloride
(CAS: 849-55-8)

Nylidrin hydrochloride is a beta-adrenergic agonist. It was an effective inhibitor of IgE-mediated release of histamine from passively sensitized rat peritoneal...

CAS 56776-01-3 Tulobuterol hydrochloride

Tulobuterol hydrochloride
(CAS: 56776-01-3)

Tulobuterol hydrochloride is a salt form of Tulobuterol, which is a long-acting beta2-adrenergic receptor agonist.

CAS 159182-43-1 L-755,507

L-755,507
(CAS: 159182-43-1)

L-755,507 is a potent, selective and novel β3-adrenergic receptor (β3-AR) partial agonist with an EC50 value of 0.43 nM. It is over 440-fold selectivity for β3 ...

CAS 24047-25-4 Guanoxabenz

Guanoxabenz
(CAS: 24047-25-4)

Guanoxabenz, a metabolite of guanaben, is an α2 adrenergic receptor agonist.

CAS 29122-68-7 Atenolol

Atenolol
(CAS: 29122-68-7)

Atenolol, with antianginal and antiarrhythmic properties, it is a cardioselective beta-adrenergic blocker and used in hypertension control.

CAS 81732-65-2 Bambuterol

Bambuterol
(CAS: 81732-65-2)

Bambuterol is a long acting beta-adrenoceptor agonist (LABA) and is used in the treatment of asthma. It is an ester prodrug of the ß2-adrenergic agonist terbuta...

CAS 550-99-2 Naphazoline hydrochloride

Naphazoline hydrochloride
(CAS: 550-99-2)

Naphazoline hydrochloride is an ocular vasoconstrictor used in eye drops.

CAS 57149-07-2 Naftopidil

Naftopidil
(CAS: 57149-07-2)

Naftopidil is a selective α1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM.

CAS 54765-26-3 Lerimazoline

Lerimazoline
(CAS: 54765-26-3)

Lerimazoline is an α-adrenergic receptor agonist. It inhibits secretion of nasal mucus. It causes hypertension. It is common used in the form of hydrochloride.

CAS 56392-17-7 Metoprolol Tartrate

Metoprolol Tartrate
(CAS: 56392-17-7)

Metoprolol Tartrate is a cardioselective β-adrenergic receptor blocker with IC50 of 42 ng/mL.

CAS 19237-84-4 Prazosin Hydrochloride

Prazosin Hydrochloride
(CAS: 19237-84-4)

Prazosin HCl, a quinazoline derivative, is the first of a new chemical class of antihypertensives.

CAS 79689-25-1 DG5128

DG5128
(CAS: 79689-25-1)

DG5128, a new oral hypoglycemic agent, is an orally available preferential antagonist of α2-adrenoceptor with 7.4 times higher affinity toward α2-adrenoceptor t...

CAS 152148-64-6 A 80426 mesylate

A 80426 mesylate
(CAS: 152148-64-6)

A 80426 mesylate is a potent α2-adrenoceptor antagonist and a selective 5-HT uptake inhibitor (Ki = 2.01 and 3.77 nM, respectively). It displays low affinity fo...

CAS 856620-39-8 O-desmethyl Mebeverine alcohol hydrochloride

O-desmethyl Mebeverine alcohol hydrochlo
(CAS: 856620-39-8)

O-desmethyl Mebeverine alcohol hydrochloride, a metabolite of Mebeverine, is a potent inhibitor of α1 repector, causing relaxation of the gastrointestinal tract...

CAS 610309-89-2 Carvedilol Phosphate

Carvedilol Phosphate
(CAS: 610309-89-2)

Carvedilol phosphate hemihydrate is a nonselective beta (β1, β2) blocker and alpha (α1) blocker, inhibits LDL oxidation (IC50 = 3.8 μM).

CAS 64208-32-8 CGP 12177 hydrochloride

CGP 12177 hydrochloride
(CAS: 64208-32-8)

CGP 12177 hydrochloride is a partial agonist of β3-adrenoceptors, and also an antagonist of β1- and β2-adrenoceptors (Ki = 0.9, 4 and 88 nM for β1, β2 and β3 re...

Chemical Structure

CAS 51-30-9 Isoprenaline HCl

Quick Inquiry

Verification code

Featured Items