Isocarboxazid - CAS 59-63-2
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Monoamine Oxidase
Isocarboxazid is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) belonging to the hydrazine class. It is primarily used to treat mood and anxiety disorders. It is also used for the treatment of Parkinson's disease and other dementia-related disorders. It is also effective in the treatment of major depression, dysthymic disorder, and atypical depression. It blocks the breakdown (oxidative deamination) of biogenic amines by inhibiting MAO, thereby increasing the concentrations of norepinephrine and 5-hydroxytrytamine at central aminergic receptors. It was developed by Validus and has been listed.
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White to Pale Yellow Solid
1-Benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine;3-Isoxazolecarboxylic acid, 5-methyl-, 2-(phenylmethyl)hydrazide;3-Isoxazolecarboxylic acid, 5-methyl-, 2-benzylhydrazide;5-Methyl-3-isoxazole-carboxylic Acid 2-Benzylhydrazide;3-(N-Benzylhydrazinocarbon
Acetontrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
-20°C Freezer
Isocarboxazid is primarily used to treat mood and anxiety disorders. It is also used for the treatment of Parkinson's disease and other dementia-related disorders. It is also effective in the treatment of major depression, dysthymic disorder, and atypical
Quality Standard:
In-house standard
Grams to Kilograms
Boiling Point:
394.5±42.0 °C | Condition: Press: 760 Torr
Melting Point:
105-106 °C
1.206±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
Canonical SMILES:
Current Developer:
Isocarboxazid was developed by Validus and has been listed.
1.Monoamine oxidase inhibitors revisited: what you should know.
Goldberg JF1, Thase ME. J Clin Psychiatry. 2013 Feb;74(2):189-91. doi: 10.4088/JCP.12ac08299.
2.Efficacy of antidepressants for late-life depression: a meta-analysis and meta-regression of placebo-controlled randomized trials.
Tedeschini E1, Levkovitz Y, Iovieno N, Ameral VE, Nelson JC, Papakostas GI. J Clin Psychiatry. 2011 Dec;72(12):1660-8. doi: 10.4088/JCP.10r06531.
OBJECTIVE: Late-life depression is an important public health issue, given the growing proportion of the elderly relative to the general population in the developed world. The purpose of this study was to examine the efficacy of antidepressants for the treatment of major depressive disorder (MDD) in elderly patients.
3.The cannabinergic system is implicated in the upregulation of central NGF protein by psychotropic drugs.
Hassanzadeh P1, Rahimpour S. Psychopharmacology (Berl). 2011 May;215(1):129-41. doi: 10.1007/s00213-010-2120-4. Epub 2010 Dec 18.
RATIONALE: Studies on the regulation of nerve growth factor (NGF) levels by psychotropics are limited in scope and the mechanism(s) remain elusive which merit further elucidation.
4.Efficacy of antidepressants and benzodiazepines in minor depression: systematic review and meta-analysis.
Barbui C1, Cipriani A, Patel V, Ayuso-Mateos JL, van Ommeren M. Br J Psychiatry. 2011 Jan;198(1):11-6, sup 1. doi: 10.1192/bjp.bp.109.076448.
BACKGROUND: Depression is a common condition that has been frequently treated with psychotropics.
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CAS 59-63-2 Isocarboxazid

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