Isocarboxazid - CAS 59-63-2
Catalog number:
59-63-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C12H13N3O2
Molecular Weight:
231.25
COA:
Inquire
Targets:
Monoamine Oxidase
Description:
Isocarboxazid is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) belonging to the hydrazine class. It is primarily used to treat mood and anxiety disorders. It is also used for the treatment of Parkinson's disease and other dementia-related disorders. It is also effective in the treatment of major depression, dysthymic disorder, and atypical depression. It blocks the breakdown (oxidative deamination) of biogenic amines by inhibiting MAO, thereby increasing the concentrations of norepinephrine and 5-hydroxytrytamine at central aminergic receptors. It was developed by Validus and has been listed.
Publictions citing BOC Sciences Products
  • >> More
Purity:
95%
Appearance:
White to Pale Yellow Solid
Synonyms:
1-Benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine;3-Isoxazolecarboxylic acid, 5-methyl-, 2-(phenylmethyl)hydrazide;3-Isoxazolecarboxylic acid, 5-methyl-, 2-benzylhydrazide;5-Methyl-3-isoxazole-carboxylic Acid 2-Benzylhydrazide;3-(N-Benzylhydrazinocarbon
Solubility:
Acetontrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Isocarboxazid is primarily used to treat mood and anxiety disorders. It is also used for the treatment of Parkinson's disease and other dementia-related disorders. It is also effective in the treatment of major depression, dysthymic disorder, and atypical
Quality Standard:
In-house standard
Quantity:
Grams to Kilograms
Boiling Point:
394.5±42.0 °C | Condition: Press: 760 Torr
Melting Point:
105-106 °C
Density:
1.206±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
XKFPYPQQHFEXRZ-UHFFFAOYSA-N
InChI:
InChI=1S/C12H13N3O2/c1-9-7-11(15-17-9)12(16)14-13-8-10-5-3-2-4-6-10/h2-7,13H,8H2,1H3,(H,14,16)
Canonical SMILES:
CC1=CC(=NO1)C(=O)NNCC2=CC=CC=C2
Current Developer:
Isocarboxazid was developed by Validus and has been listed.
1.Monoamine oxidase inhibitors revisited: what you should know.
Goldberg JF1, Thase ME. J Clin Psychiatry. 2013 Feb;74(2):189-91. doi: 10.4088/JCP.12ac08299.
2.Efficacy of antidepressants for late-life depression: a meta-analysis and meta-regression of placebo-controlled randomized trials.
Tedeschini E1, Levkovitz Y, Iovieno N, Ameral VE, Nelson JC, Papakostas GI. J Clin Psychiatry. 2011 Dec;72(12):1660-8. doi: 10.4088/JCP.10r06531.
OBJECTIVE: Late-life depression is an important public health issue, given the growing proportion of the elderly relative to the general population in the developed world. The purpose of this study was to examine the efficacy of antidepressants for the treatment of major depressive disorder (MDD) in elderly patients.
3.The cannabinergic system is implicated in the upregulation of central NGF protein by psychotropic drugs.
Hassanzadeh P1, Rahimpour S. Psychopharmacology (Berl). 2011 May;215(1):129-41. doi: 10.1007/s00213-010-2120-4. Epub 2010 Dec 18.
RATIONALE: Studies on the regulation of nerve growth factor (NGF) levels by psychotropics are limited in scope and the mechanism(s) remain elusive which merit further elucidation.
4.Efficacy of antidepressants and benzodiazepines in minor depression: systematic review and meta-analysis.
Barbui C1, Cipriani A, Patel V, Ayuso-Mateos JL, van Ommeren M. Br J Psychiatry. 2011 Jan;198(1):11-6, sup 1. doi: 10.1192/bjp.bp.109.076448.
BACKGROUND: Depression is a common condition that has been frequently treated with psychotropics.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Monoamine Oxidase Products


CAS 25905-77-5 Minaprine

Minaprine
(CAS: 25905-77-5)

Minaprine, also called as Agr 1240 or Cantor, an atypical antidepressant drug which is effective in most animal models of depression, is a reversible inhibitor ...

CAS 59-63-2 Isocarboxazid

Isocarboxazid
(CAS: 59-63-2)

Isocarboxazid is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) belonging to the hydrazine class. It is primarily used to treat mood and anxie...

CAS 136236-51-6 Rasagiline

Rasagiline
(CAS: 136236-51-6)

Rasagiline, an Indapamide derivative, has been found to be a MAO-B inhibitor that could be used to against Parkinson's disease. IC50: 4.4nM.

NS-2359
(CAS: 195875-68-4)

NS-2359, a serotonin-norepinephrine-dopamine reuptake inhibitor, may be able to reduce cocaine withdrawal symptoms, reduce cocaine craving and reduce cocaine-in...

Modaline sulfate
(CAS: 2856-75-9)

Modaline sulfate, also called as W3207B, is an active inhibitor of monoamine oxidase to treat depression.

CAS 1212-72-2 Mephentermine Hemisulphate

Mephentermine Hemisulphate
(CAS: 1212-72-2)

Hemisulphate salt form of Mephentermine which could be a cardioexcitatory agent for acting as a α-adrenoceptor agonist and it has already been used against low ...

CAS 1227-61-8 Mefexamide hydrochloride

Mefexamide hydrochloride
(CAS: 1227-61-8)

The hydrochloride salt form of Mefexamide which is a psychostimulant.

CAS 51-12-7 NIALAMIDE

NIALAMIDE
(CAS: 51-12-7)

Nialamide is used as an antidepressant for it is a monoamine oxidase inhibitor (MAOI) of the hydrazine class. It might be efficient under the combination action...

CAS 103878-84-8 Lazabemide hydrate

Lazabemide hydrate
(CAS: 103878-84-8)

Lazabemide, a pyridine derivative, is a reversible and selective monoamine oxidase B inhibitor that has probable effect for Parkinson's disease. IC50: 30 nM. It...

CAS 305-33-9 Iproniazid phosphate

Iproniazid phosphate
(CAS: 305-33-9)

Iproniazid phosphate is a non-selective, irreversible inhibitor of monoamine oxidase (MAOI) that has potential to treat hypertension.

CAS 856867-55-5 Tedizolid Phosphate

Tedizolid Phosphate
(CAS: 856867-55-5)

Torezolid phosphate is a novel oxazolidinone for gram-positive infections, has an IC50 of 8.7 μM and 5.7 μM for monoamine oxidase (MAO)-A and MAO-B, respectivel...

CAS 120635-25-8 Mofegiline HCl

Mofegiline HCl
(CAS: 120635-25-8)

The hydrochloride salt form of Mofegiline which is an irreversible inhibitor of MAO-B and was studied about its potential effect against Parkinson's disease and...

CAS 161735-79-1 Rasagiline Mesylate

Rasagiline Mesylate
(CAS: 161735-79-1)

Rasagiline (N-propargyl-1-(R)-aminoindan) is a novel, highly potent irreversible monoamine oxidase (MAO)-B inhibitor, anti-Parkinsonian drug.

CAS 133865-89-1 Safinamide

Safinamide
(CAS: 133865-89-1)

Safinamide, a selective MAO-B inhibitor, could be effective against Parkinson’s disease for patients mid-to-late-stage. IC50: 98 nM.

Ro 41-1049 hydrochloride
(CAS: 127917-66-2)

The hydrochloride salt form of Ro 41-1049 which is a MAO-A inhibitor and probably could be used in the study of Parkinson's disease.

CAS 202844-10-8 Indantadol

Indantadol
(CAS: 202844-10-8)

Indantadol is a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain.

CAS 155-09-9 Tranyl cipromine

Tranyl cipromine
(CAS: 155-09-9)

Tranylcypromine, an amphetamine derivative, has been found to be a MAO inhibitor that could be used an antidepressant agent and anxiolytic drug.

CAS 555-57-7 Pargyline

Pargyline
(CAS: 555-57-7)

Pargyline is a monoamine oxidase B (MAO-B) inhibitor with antihypertensive properties(IC50=8.2 nM), and has been found to bind with high affinity to the I2 imid...

Brofaromine Hydrochloride
(CAS: 63638-90-4)

Brofaromine Hydrochloride is a reversible inhibitor of monoamine oxidase A(RIMA). It acts on norepinephrine, epinephrine, serotonin and dopamine. It was mainly ...

CAS 537-15-5 Rosmarinic acid racemate

Rosmarinic acid racemate
(CAS: 537-15-5)

Rosmarinic acid racemate, the racemate of Rosmarinic acid, is found in many medicinal species of the plant Lamiaceae including Perilla frutescens. Rosmarinic ac...

Chemical Structure

CAS 59-63-2 Isocarboxazid

Quick Inquiry

Verification code

Featured Items