Isoalantolactone - CAS 470-17-7
Catalog number: 470-17-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H20O2
Molecular Weight:
232.32
COA:
Inquire
Targets:
Others
Description:
Isoalantolactone has the capacity to inhibit tumor cell growth through induction of apoptosis.
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥98%
Appearance:
White solid
Synonyms:
11(13)-dien-12-oicacid,8-beta-hydroxy-eudesma-4(14gamma-lactone;ISOALANTOACTONE;ISOALANTOLACTONE;ISOHELENIN;(3ar,4as,8ar,9ar)-8a-methyl-3,5-dimethylene-decahydro-naphtho[2,3-b]furan-2-one;methyl-3,5-bis(methylene)-,(3aR,4aS,8aR,9aR)-;Naphtho[2,3-b]furan-2
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
anti-microbial
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
CVUANYCQTOGILD-QVHKTLOISA-N
InChI:
1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h11-13H,1-2,4-8H2,3H3/t11-,12+,13-,15-/m1/s1
Canonical SMILES:
CC12CCCC(=C)C1CC3C(C2)OC(=O)C3=C
1.Isoalantolactone induces autophagic cell death in SKOV₃ human ovarian carcinoma cells via upregulation of PEA-15.
Weng Z1, Gao H2, Hu J3, Fan Y1, Wang H2, Li L1. Oncol Rep. 2016 Feb;35(2):833-40. doi: 10.3892/or.2015.4461. Epub 2015 Nov 26.
We investigated the effects of isoalantolactone on cell growth inhibition and underlying cell death mechanisms in SKOV3 human ovarian cancer cells. The effects of isoalantolactone on cell proliferation and cell cycle were examined by EdU incorporation assay and DNA content assay. Western blotting was performed to determine the protein expression effects of isoalantolactone on cell cycle‑related proteins, autophagic regulators and PEA‑15. Autophagic vacuoles were observed by acridine orange staining. PEA‑15 knockdown by siRNA was used to confirm that PEA‑15 was involved in isoalantolactone‑induced autophagy of SKOV3 cells. Isoalantolactone inhibited the viability and proliferation of SKOV3 cells in a dose‑ and time‑dependent fashion. Isoalantolactone induced cell cycle arrest at G2/M phase and decreased the expression of cell cycle‑related proteins cyclin B1 and CDK1 in SKOV3 cells. Accordingly, isoalantolactone also induced SKOV3 cell autophagy via accumulation of autophagic vacuoles in the cytoplasm, increased Beclin1 protein expression, and increased LC3 cleavage.
2.Pharmacokinetics, tissue distribution and excretion of isoalantolactone and alantolactone in rats after oral administration of Radix Inulae extract.
Xu R1, Zhou G2, Peng Y3, Wang M4, Li X5. Molecules. 2015 Apr 28;20(5):7719-36. doi: 10.3390/molecules20057719.
Radix Inulae is endemic to China and has been used in traditional medicine to treat upper body pain, emesis and diarrhoea, and to eliminate parasites. Here, an UPLC-MS/MS method was developed and applied to study the pharmacokinetics, distribution and excretion of isoalantolactone and alantolactone, which are two main active sesquiterpene lactones in Radix Inulae, in Sprague-Dawley rats following oral administration of total Radix Inulae extract. Isoalantolactone, alantolactone and osthole (internal standard) were prepared using acetonitrile precipitation, and the separation of isoalantolactone and alantolactone was achieved by isocratic elution using water (containing 0.1% formic acid) and acetonitrile as the mobile phase using a ZORBAX Eclipse Plus C18 column. The total run time was 6.4 min. The present study showed poor absorption of isoalantolactone and alantolactone in vivo. The apparent Cmax, Tmax, T1/2 and total exposure (AUC0-12h) in rat plasma were 37.
3.Isoalantolactone Enhances the Radiosensitivity of UMSCC-10A Cells via Specific Inhibition of Erk1/2 Phosphorylation.
Fan Y1, Weng Z1, Gao H2, Hu J3, Wang H2, Li L1, Liu H1. PLoS One. 2015 Dec 30;10(12):e0145790. doi: 10.1371/journal.pone.0145790. eCollection 2015.
BACKGROUND: Although radiotherapy is one of the mainstream approaches for the treatment of head and neck squamous cell carcinoma (HNSCC), this cancer is always associated with resistance to radiation. In this study, the mechanism of action of isoalantolactone as well as its radiosensitizing effect was investigated in UMSCC-10A cells.
4.Simultaneous determination of chlorogenic acid, caffeic acid, alantolactone and isoalantolactone in Inula helenium by HPLC.
Wang J1, Zhao YM2, Zhang ML1, Shi QW3. J Chromatogr Sci. 2015 Apr;53(4):526-30. doi: 10.1093/chromsci/bmu079. Epub 2014 Jul 4.
A rapid and sensitive high-performance liquid chromatographic (HPLC) method was developed for the simultaneous separation and determination of chlorogenic acid, caffeic acid, alantolactone and isoalantolactone in Inula helenium. The HPLC separation was performed on an Elite Hypersil C18 column (200 × 4.6 mm i.d., 5 µm particle size) with a gradient elution of solvent A (acetonitrile) and solvent B (0.1% phosphoric acid in water) at a flow rate of 1.0 mL/min. Detection was monitored at 225 nm. The recovery of chlorogenic acid ranged from 95.6 to 107.7%, the recovery of caffeic acid ranged from 95.4 to 104.2%, the recovery of alantolactone ranged from 95.8 to 100.8% and the recovery of isoalantolactone ranged from 96.5 to 102.3%. The retention times for chlorogenic acid, caffeic acid, alantolactone and isoalantolactone were 5.2, 7.1, 25.6 and 26.6 min with the limits of detection of 0.069, 0.021, 0.039 and 0.051 µg/mL, respectively. Relative standard deviation for the intra-day and inter-day was ≤2.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


RG3039
(CAS: 1005504-62-0)

RG3039 is a potent DcpS inhibitor. It is used for the treatment for spinal muscular atrophy(SMA), which is caused by deletion or mutation of both copies of the ...

CAS 141195-77-9 Cefovecin sodium

Cefovecin sodium
(CAS: 141195-77-9)

Cefovecin Sodium is an antibiotic of the cephalosporin class. It is used for the treatment of skin infections caused by Pasturella multocida in cats, and Staphy...

CAS 87701-68-6 Alismoxide

Alismoxide
(CAS: 87701-68-6)

Alismoxide is a natural product extracted from the tubers of Alisma plantago-aquatica. It has anti-inflammatory effects.

CAS 3416-24-8 D-Glucosamine (Free Base)

D-Glucosamine (Free Base)
(CAS: 3416-24-8)

An amino sugar, part of the structure of the polysaccharides chitosan and chitin, is made naturally in the form of glucosamine-6-phosphate, and is the biochemic...

Navamepent
(CAS: 1251537-11-7)

Navamepent is an inflammation mediator inhibitor and lipid modulator originated by Resolvyx Pharmaceuticals and licensed to Auven Therapeutics in 2011. Treatmen...

CAS 50-70-4 Sorbitol

Sorbitol
(CAS: 50-70-4)

Sorbitol is a sugar alcohol and a sugar substitute.

CAS 5466-77-3 Octinoxate

Octinoxate
(CAS: 5466-77-3)

Octinoxate is an organic compound that is an ingredient in some sunscreens and lip balms used in sunscreens and other cosmetics

CAS 136-40-3 Phenazopyridine Hydrochloride

Phenazopyridine Hydrochloride
(CAS: 136-40-3)

Phenazopyridine Hydrochloride is a local analgesic that has been used in urinary tract disorders.

CAS 4065-45-6 Sulisobenzone

Sulisobenzone
(CAS: 4065-45-6)

Sulisobenzoneis a UV filter which protects the skin from damage by UVB and short-wave UVA ultraviolet light

CAS 1632032-53-1 LB-100

LB-100
(CAS: 1632032-53-1)

LB-100 is a water solubleprotein phosphatase 2A (PP2A)inhibitor(IC50= 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells) and enhanced the effects of sorafenib in H...

CAS 1421227-52-2 WS3

WS3
(CAS: 1421227-52-2)

WS3 induces proliferation of the mouse β cell line R7T1 with EC50 of 0.074 μM.

CAS 5451-09-2 5-Aminolevulinic acid hydrochloride

5-Aminolevulinic acid hydrochloride
(CAS: 5451-09-2)

5-Aminolevulinic acid HCl is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles. 5-Aminolevulinic acid is used as a p...

CAS 109552-15-0 Pamidronate disodium pentahydrate

Pamidronate disodium pentahydrate
(CAS: 109552-15-0)

Pamidronate disodium pentahydrate is a nitrogen-containing bisphosphonate, used to prevent osteoporosis.

CAS 80681-45-4 Prim-o-glucosylcimifugin

Prim-o-glucosylcimifugin
(CAS: 80681-45-4)

Prim-O-glucosylcimifugin is a natural product extracted from the root of Saposhnikovia divaricata (Turcz.) Schischk. It can inhibit the proliferation of SMC(smo...

CAS 6902-77-8 Genipin

Genipin
(CAS: 6902-77-8)

Genipin, a compound isolated from Gardenis jasminoides Ellis fruits, is a cell-permeable inhibitor of UCP2 activity. Genipin also exhibits anti-inflammatory and...

CAS 74115-24-5 Clofentezine

Clofentezine
(CAS: 74115-24-5)

Clofentezine is an active substance of plant protection product used as pesticide, acaricide. It belongs to the chemical family of quinoxalines. It is used in a...

Cgp 43902A
(CAS: 124076-31-9)

Cgp 43902A is a bio-active molecular, but no detailed information has been published yet.

CAS 4360-12-7 Ajmaline:Ajmalan-17,21-diol,(17R,21)-,

Ajmaline:Ajmalan-17,21-diol,(17R,21)-,
(CAS: 4360-12-7)

Ajmaline is an alkaloid which could extracted from Rauwolfia serpentina. It is an antiarrhythmic agent, acting through changing the shreshold and the shape of c...

CAS 2135-17-3 Flumethasone

Flumethasone
(CAS: 2135-17-3)

Flumethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in...

CAS 60-27-5 Creatinine

Creatinine
(CAS: 60-27-5)

Creatinine is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.

Chemical Structure

CAS 470-17-7 Isoalantolactone

Quick Inquiry

Verification code

Featured Items