Isoacteoside - CAS 61303-13-7
Catalog number: 61303-13-7
Category: Inhibitor
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Molecular Formula:
C29H36O15
Molecular Weight:
624.59
COA:
Inquire
Targets:
Others
Description:
Isoacteoside is a natural compound which exhibit significant inhibition of advanced glycation end product formation, compared with those of aminoguanidine and quercetin as positive controls.
Purity:
>98%
Synonyms:
Isoverbascoside
MSDS:
Inquire
InChIKey:
FNMHEHXNBNCPCI-QEOJJFGVSA-N
InChI:
InChI=1S/C29H36O15/c1-13-22(35)24(37)25(38)29(42-13)44-27-23(36)20(12-41-21(34)7-4-14-2-5-16(30)18(32)10-14)43-28(26(27)39)40-9-8-15-3-6-17(31)19(33)11-15/h2-7,10-11,13,20,22-33,35-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27-,28+,29-/m0/s1
Canonical SMILES:
CC1C(C(C(C(O1)OC2C(C(OC(C2O)OCCC3=CC(=C(C=C3)O)O)COC(=O)C=CC4=CC(=C(C=C4)O)O)O)O)O)O
1.Amphipaniculosides A-D, triterpenoid glycosides, and amphipaniculoside E, an aliphatic alcohol glycoside from the leaves of Amphilophium paniculatum.
Samy MN1, Khalil HE2, Sugimoto S3, Matsunami K4, Otsuka H5, Kamel MS2. Phytochemistry. 2015 Jul;115:261-8. doi: 10.1016/j.phytochem.2015.02.020. Epub 2015 Mar 21.
Four new triterpenoids; One oleanane-, one ursane- and two cycloartane-type triterpenoids, named amphipaniculosides A-D, in addition to one new aliphatic alcohol glycoside, named amphipaniculoside E, were isolated from the 1-BuOH fraction of the leaves of Amphilophium paniculatum (L.) Kunth., together with five known compounds, (+)-lyoniresinol 3α-O-β-D-glucopyranoside, (-)-lyoniresinol 3α-O-β-D-glucopyranoside, acteoside (verbascoside), isoacteoside (isoverbascoside), and luteolin 7-O-β-D-glucopyranoside. Their structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments ((1)H, (13)C, DEPT, COSY, ROESY, HSQC, HMBC) in combination with HR-ESI-MS and by comparisons of their physical and spectroscopic data with literature values.
2.[Identification of Chinese Traditional Medicine Cistanches Herba from Different Places by HPLC-ESI-MS and FTIR Methods].
Zhou Y, Li W, Han LF, Song XB, Li PF, Wang R, Zhang B-. Guang Pu Xue Yu Guang Pu Fen Xi. 2015 Apr;35(4):1056-61.
Five samples of Cistanches Herba from different places were analyzed by HPLC-ESI-MS and FTIR methods. The effective compositions in Cistanches Herba including cistanoside A, echinacoside, acteoside , isoacteoside, 2'-actylacteoside, cistanoside C and tubluoside B were determined by HPLC-MS. The common peak ratio and variant peak ratio were calculated by FTIR spectroscopy of the five samples and the dual index sequence of common peak ratio and variant peak ratio were established. The results showed that the evaluation results of the samples by the two methods were the same. The general fake plant Cynomorii Herba could be identified by FTIR. HPLC-ESI-MS, which has high sensitivity and rapid determination procedure, can be used to evaluate quality of Cistanches Herba by quantitative analysis of the primary compositions. FTIR is a non-destructive analysis method. without complicated extraction and separation procedures to the samples. The absorption strength and the absorption shape were the synergistic effect of the functional groups and the nestification of the components in Cistanches Herba.
3.Anti-inflammatory effects of isoacteoside from Abeliophyllum distichum.
Nam SY1, Kim HY, Yoou MS, Kim AH, Park BJ, Jeong HJ, Kim HM. Immunopharmacol Immunotoxicol. 2015 Jun;37(3):258-64. doi: 10.3109/08923973.2015.1026604. Epub 2015 May 15.
Isoacteoside, a dihydroxypheynylethyl glycoside, is a major bioactive component of Abeliophyllum distichum (White Forsythia) which is a deciduous shrub native to the south and central areas of Korea. The present study is designed to evaluate the anti-inflammatory activities and underlying mechanisms of isoacteoside in human mast cell line, HMC-1 cells. We isolated isoacteoside from A. distichum. The anti-inflammatory effect of isoacteoside was investigated in HMC-1 cells by studying the following markers: phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor alpha (TNF-α) secretion and mRNA expression by ELISA and RT-PCR, respectively. In addition, mechanism related to anti-inflammatory was investigated by Western blotting. Isoacteoside significantly suppressed the production and mRNA expression of proinflammatory cytokines including IL-1β, IL-6, IL-8 and TNF-α in PMACI-stimulated HMC-1 cells without cytotoxicity.
4.Anti-inflammatory effects of isoacteoside from Abeliophyllum distichum.
Nam SY1, Kim HY, Yoou MS, Kim AH, Park BJ, Jeong HJ, Kim HM. Immunopharmacol Immunotoxicol. 2015 Jun;37(3):258-64. doi: 10.3109/08923973.2015.1026604. Epub 2015 May 15.
Isoacteoside, a dihydroxypheynylethyl glycoside, is a major bioactive component of Abeliophyllum distichum (White Forsythia) which is a deciduous shrub native to the south and central areas of Korea. The present study is designed to evaluate the anti-inflammatory activities and underlying mechanisms of isoacteoside in human mast cell line, HMC-1 cells. We isolated isoacteoside from A. distichum. The anti-inflammatory effect of isoacteoside was investigated in HMC-1 cells by studying the following markers: phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor alpha (TNF-α) secretion and mRNA expression by ELISA and RT-PCR, respectively. In addition, mechanism related to anti-inflammatory was investigated by Western blotting. Isoacteoside significantly suppressed the production and mRNA expression of proinflammatory cytokines including IL-1β, IL-6, IL-8 and TNF-α in PMACI-stimulated HMC-1 cells without cytotoxicity.
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CAS 61303-13-7 Isoacteoside

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