ISO-1 - CAS 478336-92-4
Catalog number:
478336-92-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C12H13NO4
Molecular Weight:
235.24
COA:
Inquire
Targets:
Others
Description:
ISO-1 is an inhibitor of the dopachrome tautomerase activity of MIF. It blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages and improves the survival of mice following sepsis.It also demonstrates protective effects in airway and gastrointestinal inflammation in mice.
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Purity:
>98%
Synonyms:
MIF Antagonist
MSDS:
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1.The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD.
Russell KE1, Chung KF1, Clarke CJ1, Durham AL1, Mallia P2, Footitt J2, Johnston SL2, Barnes PJ1, Hall SR3, Simpson KD3, Starkey MR4, Hansbro PM4, Adcock IM1, Wiegman CH1. PLoS One. 2016 Jan 11;11(1):e0146102. doi: 10.1371/journal.pone.0146102. eCollection 2016.
INTRODUCTION: Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine associated with acute and chronic inflammatory disorders and corticosteroid insensitivity. Its expression in the airways of patients with chronic obstructive pulmonary disease (COPD), a relatively steroid insensitive inflammatory disease is unclear, however.
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CAS 478336-92-4 ISO-1

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