|Description||ISA-2011B is a Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα) inhibitor. Research shows that the overexpression of PIP5K1α is associated with poor prognosis in prostate cancer and correlates with an elevated level of the androgen receptor. ISA-2011B can inhibit growth of tumor cells in xenograft mice, which is mediated by targeting PIP5K1α-associated PI3K/AKT and the downstream survival, proliferation, and invasion pathways.|
|Synonyms||ISA2011B; ISA 2011B; ISA-2011B; ISA2011-B; ISA 2011-B; ISA-2011-B. (5S,10aS)-5-(5-chloro-1H-indol-3-yl)-9-methyl-8,9,10a,11-tetrahydro-5H-[1,3]dioxolo[4,5-g]pyrazino[1,2-b]isoquinoline-7,10-dione|
|Solubility||Soluble in DMSO|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
SB 747651A tetrahydrochloride is a potent and ATP-competitive inhibitor of mitogen- and stress-activated kinase 1 (MSK1) with an IC50 value of 11 nM.
PROTO-1, a benzothiophene carboxamide, shows significant protection of hair cells over a broad range of neomycin concentrations, from 25 μM to 400 μM.
4-Hexylresorcinol, a phenol derivative, could be commonly used as antioxidant, vermifuge and food additives.
Zoniporide dihydrochloride is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor with selectivity over other NHE isoforms (Ki = 14, 2200 and 220000 n...
Articaine is a dental amide-type local anesthetic. It is the most widely used local anesthetic in a number of European countries and is available in many countr...
Propagermanium is an organometallic compound of germanium that is sold as an alternative medicine for the treatment of Hepatitis B under the development of Aste...
NSC 23005 sodium
NSC23005 sodium is a p18INK inhibitor. It can promote hematopoietic stem cell expansion with ED50 of 5.21 nM.
SB 747651A dihydrochloride
SB 747651A dihydrochloride is a potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC50 = 11 nM in an in vitro kinase assay). SB 7...