|Description||Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. It inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice. It up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy. It also produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions.|
|Synonyms||Dicloguamine maleate; MN1695|
Anisodamine is a alkaloid shown to be a weak antagonist of α1-adrenoceptors, blocking WB-4101 and clonidine by binding in brain membrane preparations.
Propantheline Bromide is an antimuscarinic agent used as an antispasmodic for the treatment of ulcers.
Otilonium Bromide is an antimuscarinic used as a spasmolytic agent.
Muscarinic M3 receptor antagoinst. Used in treatment of urinary incontinence.
Glycopyrrolate bromide is a muscarinic competitive antagonist used as an antispasmodic.
Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Five subtypes (M1-5) have been identified, which preferentially coup...
Diphemanil Methylsulfate is a quaternary ammonium anticholinergic.It binds muscarinic acetycholine receptors (mAchR).
Aclidinium Bromide(LAS 34273; LAS-W 330) is a long-acting, inhaled muscarinic antagonist as a maintenance treatment for chronic obstructive pulmonary disease (C...
Flavoxate is an anticholinergic with antimuscarinic effects. Its muscle relaxant properties may be due to a direct action on the smooth muscle rather than by an...
Solifenacin is a competitive cholinergic receptor antagonist.Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class.
Pyrithioxin, a pyridine thiol derivatives, could be used in the treatment of traumatic brain injury sequelae and some sorts of cerebral infarct patients with He...
Mepenzolate Bromide is a muscarinic antagonist used to treat gastrointestinal disorders, and decreases the severity of elastase-induced airspace enlargement and...
Acetylcholine is an organic molecule that acts as a neurotransmitter in many organisms, including humans.
Tubocurarine hydrochloride pentahydrate
Tubocurarine is a toxic alkaloid. It is an acetylcholine receptor (AChR)-blocking agent. Tubocurarine is now rarely used as an adjunct for clinical anesthesia b...
pilocarpine nitrate is a non-selective muscarinic receptor agonist that can be used to treat glaucoma.
Methacholine chloride, a synthetic choline ester, is pharmaceutical agent acting as a β2-adrenergic agonist used in the treatment of pulmonary and respiratory d...
Arecoline is a muscarinic acetylcholine receptor agonist.
Tarafenacin is a highly selective M3 muscarinic receptor antagonist. It was the most potent in inhibiting carbachol-induced bladder contractions of the anti-ch...
MK-0969 is an Muscarinic M3 antagonist which has the potential for the treatment of chronic obstructive pulmonary diseases.
VU 0357017 hydrochloride
The hydrochloride salt form of VU0357017 which is a selective M1 agonists and has been found to be probably effective in the treatment of hippocampal-dependent ...