|Description||IP7e is a potent Nurr1 (NR4A2) activator with EC50 value of 3.9 nM, which is important in the development and maintenance of midbrain dopaminergic neurons and is independent of endogenous activation. It suppresses NF-κB signaling. It reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE). It is brain penetrant and orally bioavailable.|
|Purity||≥98% by HPLC|
|Synonyms||IP7e; IP 7e; IP-7e; isoxazolo-pyridinone 7e; 6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one|
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