Iothalamic Acid - CAS 2276-90-6
Catalog number: 2276-90-6
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C11H9I3N2O4
Molecular Weight:
613.91
COA:
Inquire
Targets:
Others
Description:
Iothalamic Acid, similar to those of diatrizoic acid, as conventional ionic contrast medioum Iothalamic Acid displayed the same level of nephrotoxicity against rat and human renal epithelial cells.
Purity:
95%
Appearance:
Off-white to white powder
Synonyms:
3-acetamido-2,4,6-triiodo-5-(methylcarbamoyl)benzoic acid Acid, Iotalamic Acid, Iothalamic Acid, Methalamic Angio Conray Angio-Conray AngioConray Conray 420 Iodothalamate Iotalamic Acid Iothalamate Iothalamate, Sodium Iothalamic Acid Iothalamic Acid, Calc
Solubility:
Soluble in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -89℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Quantity:
Data not available, please inquire.
Boiling Point:
520.2ºC at 760 mmHg
Melting Point:
285ºC
Density:
2.54 g/cm3
InChIKey:
UXIGWFXRQKWHHA-UHFFFAOYSA-N
InChI:
1S/C11H9I3N2O4/c1-3(17)16-9-7(13)4(10(18)15-2)6(12)5(8(9)14)11(19)20/h1-2H3,(H,15,18)(H,16,17)(H,19,20)
Canonical SMILES:
CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)C(=O)NC)I
1.Modified radioiodination and quality control methods for [125I]sodium iothalamate.
Hung JC;Herold TJ Nucl Med Biol. 1994 Oct;21(7):1011-2.
[125I]Sodium iothalamate can be prepared by the isotope-exchange method with the use of a contrast medium preparation (i.e. iothalamate sodium injection, USP, 80%). The initial isolation and purification of iothalamate from the contrast medium solution for radioiodination is tedious and time-consuming (i.e. 1 1/2 h for purification and overnight for drying). The new method uses iothalamic acid to replace iothalamate sodium injection as a starting material and reduces the heating time and multiple acid-washing steps during radioiodination to expedite the radiolabelling process. The radiochemical purity (RCP) of [125I]sodium iothalamate obtained from the new method was 98.9 +/- 1.3% (n = 30) versus RCP value of 99.2 +/- 1.0% (n = 25) from the old method with no significant differences between the two groups of RCP values. An RCP chromatographical system to separate and migrate the radiochemical species of [125I]sodium iothalamate from the origin is described in this paper.
2.[Quantiative determination of radiopaque contrast media by means of HPLC. I. Determination of diatrizoic acid, iothalamic acid and iodamide].
La Rotonda MI;Schettino O Boll Soc Ital Biol Sper. 1978 Dec 30;54(24):2583-9.
A rapid method for the quantitative analysis of radiopaque contrast media HPLC is described. Method can greatly help in solving problems of clinical and forensic interest.
3.Column-switching liquid chromatographic method for the simultaneous determination of iothalamic acid and creatinine in biological fluids.
Seki T;Orita Y;Yamamoto S;Ueda N;Yanagihara Y;Noguchi K J Chromatogr A. 1994 Feb 11;661(1-2):113-9.
A column-switching liquid chromatographic method for simultaneous determination of iothalamate and creatinine in human serum and urine was developed. Iothalamate and creatinine were separated on a weakly acidic ion-exchange column (C1) by ion-exclusion chromatography and iothalamate excluded from the column was purified by gel chromatography on a hydrophilic gel column (C2) and then by ion-exchange chromatography on a weakly basic ion-exchange column (C3). Creatinine that was eluted from C1 after iothalamate was transferred to a hydrophilic gel column (C4) and then to a strongly acidic ion-exchange column (C5). The mobile phase for C1-C4 was a pH 3.8 propionate buffer (propionic acid-NaOH = 0.35 + 0.035 mol/kg in water) and a pH 5.6 propionate buffer (propionic acid-NaOH = 0.04 + 0.035 mol/kg in water) was used for C5. Diluted serum and urine samples could be injected directly on to C1, as the matrix of C1 is hydrophilic and C1 is backflushed after the transfer of the creatinine fraction from C1 to C4. Iothalamate and creatinine in the eluates were determined by measuring their ultraviolet absorption at 245 and 234 nm, respectively. The precision (R.S.D.) of the chromatographic method was 1.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 1435467-38-1 PF-1355

PF-1355
(CAS: 1435467-38-1)

PF-1355 is a selective, mechanism-based inhibitor of myeloperoxidase (MPO) (IC50 = 1.5 μM in LPS-stimulated human whole blood) with excellent selectivity for MP...

MS049 oxalate salt

MS049 oxalate salt is a potent and selective PRMT4 and PRMT6 inhibitor. MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0...

CAS 131707-25-0 Arbidol

Arbidol
(CAS: 131707-25-0)

Arbidol is an antiviral agent using for the treatment of influenza infection in Russia and China. It inhibits membrane fusion and prevents contact between the v...

CAS 19666-30-9 Oxadiazon

Oxadiazon
(CAS: 19666-30-9)

Oxadiazon is a widely used herbicide that is selective for the control of grasses and annual weeds.

CAS 25046-79-1 Glisoxepide

Glisoxepide
(CAS: 25046-79-1)

Glisoxepide, a second-generation sulfonylurea, exerts greater binding affinity than the first-generation compounds. With antihyperglycemic activity, Glisoxepide...

T7 Tag Peptide

T7 Tag Peptide, an epitope tag composed of an 11-residue peptide encoded from the leader sequence of the T7 bacteriophage gene10, and serves as a tag in many ex...

CAS 8067-24-1 Codergocrine mesilate

Codergocrine mesilate
(CAS: 8067-24-1)

Codergocrine mesilate is a mixture of the methanesulfonate salts of three dihydrogenated ergot alkaloids. It binds with high affinity to the GABAA receptor Cl- ...

13-Oxyingenol Dodecanoate
(CAS: 54706-70-6)

13-Oxyingenol Dodecanoate is a derivative of Ingenol acts as a diterpene compound with antinematodal activity.

Chemical Structure

CAS 2276-90-6 Iothalamic Acid

Quick Inquiry

Verification code

Featured Items